BeKm-1

Modify Date: 2024-04-05 18:00:22

BeKm-1 Structure
BeKm-1 structure
 Common Name BeKm-1
CAS Number 524962-01-4 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula C174H261N51O52S6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BeKm-1


A potent, selective peptide inhibitor of hERG channel with IC50 of 3.3 nM for hERG1 channels; displays no effect at 100 nM on hEAG, hSK1, rSK2, hIK, hBK, KCNQ1/KCNE1, KCNQ2/KCNQ3, KCNQ4 channels, and minimal effect on rELK1; prolongs QTc intervals significantly and concentration-dependently (4.7 and 16.3% at 10 and 100 nM, respectively).

 Names

Name BeKm 1

 BeKm-1 Biological Activity

Description A potent, selective peptide inhibitor of hERG channel with IC50 of 3.3 nM for hERG1 channels; displays no effect at 100 nM on hEAG, hSK1, rSK2, hIK, hBK, KCNQ1/KCNE1, KCNQ2/KCNQ3, KCNQ4 channels, and minimal effect on rELK1; prolongs QTc intervals significantly and concentration-dependently (4.7 and 16.3% at 10 and 100 nM, respectively).
References References 1. Korolkova YV, et al. J Biol Chem. 2002 Nov 8;277(45):43104-9. 2. Korolkova YV, et al. J Biol Chem. 2001 Mar 30;276(13):9868-76. 3. Qu Y, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):2-8. 4. Qu Y, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):2-8. View Related Products by Target Potassium Channel

 Chemical & Physical Properties

Molecular Formula C174H261N51O52S6
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Chemsrc provides BeKm-1(CAS#:524962-01-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of BeKm-1 are included as well.>> amp version: BeKm-1

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