berythromycin

Modify Date: 2024-01-02 20:12:09

berythromycin Structure
berythromycin structure
Common Name berythromycin
CAS Number 527-75-3 Molecular Weight 717.927
Density 1.2±0.1 g/cm3 Boiling Point 807.6±65.0 °C at 760 mmHg
Molecular Formula C37H67NO12 Melting Point 168-170ºC (dec)
MSDS N/A Flash Point 442.2±34.3 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name erythromycin B
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 807.6±65.0 °C at 760 mmHg
Melting Point 168-170ºC (dec)
Molecular Formula C37H67NO12
Molecular Weight 717.927
Flash Point 442.2±34.3 °C
Exact Mass 717.466309
PSA 173.68000
LogP 3.12
Vapour Pressure 0.0±6.5 mmHg at 25°C
Index of Refraction 1.527
Storage condition 20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KF4700000
CHEMICAL NAME :
Erythromycin, 12-deoxy-
CAS REGISTRY NUMBER :
527-75-3
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C37-H67-N-O12
MOLECULAR WEIGHT :
718.05
WISWESSER LINE NOTATION :
T-14-VO GVTJ C2 D1 EQ F1 H1 JQ J1 L1 N1 KO- BT6OTJ CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO1 D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 2,58,1980

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36
Safety Phrases 26
RIDADR NONH for all modes of transport

 Synthetic Route

 Precursor & DownStream

Precursor  2

DownStream  0

 Articles8

More Articles
A simple and rapid confirmatory assay for analyzing antibiotic residues of the macrolide class and lincomycin in bovine milk and yoghurt: hot water extraction followed by liquid chromatography/tandem mass spectrometry.

Rapid Commun. Mass Spectrom. 21(2) , 237-46, (2007)

A rapid and simple sample preparation procedure for determining residues of antibiotics of the class of macrolides and lincomycin in whole milk and yoghurt by liquid chromatography/tandem mass spectro...

Acid-catalyzed degradation of clarithromycin and erythromycin B: a comparative study using NMR spectroscopy.

J. Med. Chem. 43(3) , 467-74, (2000)

One of the major drawbacks in the use of the antibiotic erythromycin A is its extreme acid sensitivity, leading to degradation in the stomach following oral administration. The modern derivative clari...

An abiotic strategy for the enantioselective synthesis of erythromycin B.

Angew. Chem. Int. Ed. Engl. 42(28) , 3278-81, (2003)

 Synonyms

12-Deoxyerythromycin
(3R,4S,5S,6R,7R,9R,11R,12S,13R,14R)-6-{[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione
berythromycinum
berythromycin
beritromicina
berythromycine
(3R,4S,6R,7R,9R,11R,12S,13R,14R)-6-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12-dihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
erythromycin B
(3R,4S,5S,6R,7R,9R,11R,12S,13R,14R)-6-{[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (non-preferred name)
berythromycinum [INN_la]
Erythromycin Impurity 2