Trisodium 6-O-phosphonato-D-gluconate

Modify Date: 2024-01-09 19:46:47

Trisodium 6-O-phosphonato-D-gluconate structure	Common Name	Trisodium 6-O-phosphonato-D-gluconate
	CAS Number	53411-70-4	Molecular Weight	342.081
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆H₁₀Na₃O₁₀P	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Trisodium 6-O-phosphonato-D-gluconate

6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite[1][2].

Name	6-Phosphogluconic acid trisodium salt
Synonym	More Synonyms

Description	6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite[1][2].
Related Catalog	Research Areas >> Metabolic Disease
Target	phosphoglucose isomerase[1]
In Vitro	6-Phosphogluconic acid trisodium (0.5-2.0 mM) completely inhibits the activity of PGI with glucose 6-phosphate (0.05- 0.5 mM) as the substrate[1].
References	[1]. Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52. [2]. Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600.

Molecular Formula	C₆H₁₀Na₃O₁₀P
Molecular Weight	342.081
Exact Mass	341.970459
PSA	203.28000
Storage condition	−20°C
Water Solubility	H2O: 50 mg/mL, clear, colorless

Trisodium 6-O-phosphonato-D-gluconate MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2931900090

HS Code	2931900090
Summary	2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%