2H-1,3,2-Oxazaphosphorin-2-amine,N,N-diethyltetrahydro-, 2-oxide

Modify Date: 2024-04-03 22:07:02

2H-1,3,2-Oxazaphosphorin-2-amine,N,N-diethyltetrahydro-, 2-oxide Structure
2H-1,3,2-Oxazaphosphorin-2-amine,N,N-diethyltetrahydro-, 2-oxide structure
Common Name 2H-1,3,2-Oxazaphosphorin-2-amine,N,N-diethyltetrahydro-, 2-oxide
CAS Number 53859-37-3 Molecular Weight 192.19600
Density 1.11g/cm3 Boiling Point 249ºC at 760mmHg
Molecular Formula C7H17N2O2P Melting Point N/A
MSDS N/A Flash Point 104.4ºC

 Names

Name N,N-diethyl-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.11g/cm3
Boiling Point 249ºC at 760mmHg
Molecular Formula C7H17N2O2P
Molecular Weight 192.19600
Flash Point 104.4ºC
Exact Mass 192.10300
PSA 51.38000
LogP 1.77500
Index of Refraction 1.473

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP5788700
CHEMICAL NAME :
2H-1,3,2-Oxazaphosphorin-2-amine, tetrahydro-N,N-diethyl-, 2-oxide
CAS REGISTRY NUMBER :
53859-37-3
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C7-H17-N2-O2-P
MOLECULAR WEIGHT :
192.23
WISWESSER LINE NOTATION :
T6MPOTJ BO BN2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Bird - chicken Cells - not otherwise specified
DOSE/DURATION :
211 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 268,115,1992

 Safety Information

HS Code 2934999090

 Synthetic Route

~%

2H-1,3,2-Oxazaphosphorin-2-amine,N,N-diethyltetrahydro-, 2-oxide Structure

2H-1,3,2-Oxazap...

CAS#:53859-37-3

Literature: Farmer; Cox Journal of Medicinal Chemistry, 1975 , vol. 18, # 11 p. 1106 - 1110

~%

2H-1,3,2-Oxazaphosphorin-2-amine,N,N-diethyltetrahydro-, 2-oxide Structure

2H-1,3,2-Oxazap...

CAS#:53859-37-3

Literature: Zon,G. et al. Journal of the American Chemical Society, 1977 , vol. 99, p. 5785 - 5795

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Dechlorcyclophosphamide
B 516
N,N-Diethylcyclophosphamide
Didechlorocyclophosphamide
ASTA 7019
n,n-diethyl-1,3,2-oxazaphosphinan-2-amine 2-oxide
ASTA B 516