L-Carnitine inner salt

Modify Date: 2024-01-02 01:51:27

L-Carnitine inner salt Structure
L-Carnitine inner salt structure
 Common Name L-Carnitine inner salt
CAS Number 541-15-1 Molecular Weight 161.199
Density N/A Boiling Point N/A
Molecular Formula C7H15NO3 Melting Point 197-212 °C(lit.)
MSDS USA Flash Point N/A

 Use of L-Carnitine inner salt


L-carnitine is constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.Target: OthersL-Carnitine is an endogenous molecule involved in fatty acid metabolism, biosynthesized within the human body using amino acids: L-lysine and L-methionine, as substrates. L-Carnitine can also be found in many foods, but red meats, such as beef and lamb, are the best choices for adding carnitine into the diet [1]. Administering L-carnitine (510 mg/day) to patients with the disease. L-carnitine treatment significantly improved the total time for dozing off during the daytime, calculated from the sleep logs, compared with that of placebo-treated periods. L-carnitine efficiently increased serum acylcarnitine levels, and reduced serum triglycerides concentration [2]. L-carnitine and its derivatives show promise in the treatment of chronic conditions and diseases associated with mitochondrial dysfunction but further translational studies are needed to fully explore their potential [3].

 Names

Name (R)-carnitine
Synonym More Synonyms

 L-Carnitine inner salt Biological Activity

Description L-carnitine is constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.Target: OthersL-Carnitine is an endogenous molecule involved in fatty acid metabolism, biosynthesized within the human body using amino acids: L-lysine and L-methionine, as substrates. L-Carnitine can also be found in many foods, but red meats, such as beef and lamb, are the best choices for adding carnitine into the diet [1]. Administering L-carnitine (510 mg/day) to patients with the disease. L-carnitine treatment significantly improved the total time for dozing off during the daytime, calculated from the sleep logs, compared with that of placebo-treated periods. L-carnitine efficiently increased serum acylcarnitine levels, and reduced serum triglycerides concentration [2]. L-carnitine and its derivatives show promise in the treatment of chronic conditions and diseases associated with mitochondrial dysfunction but further translational studies are needed to fully explore their potential [3].
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Marcovina, S.M., et al., Translating the basic knowledge of mitochondrial functions to metabolic therapy: role of L-carnitine. Transl Res, 2013. 161(2): p. 73-84.

[2]. Pekala, J., et al., L-carnitine--metabolic functions and meaning in humans life. Curr Drug Metab, 2011. 12(7): p. 667-78.

[3]. Miyagawa, T., et al., Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial. PLoS One, 2013. 8(1): p. e53707.

 Chemical & Physical Properties

Melting Point 197-212 °C(lit.)
Molecular Formula C7H15NO3
Molecular Weight 161.199
Exact Mass 161.105194
PSA 60.36000
LogP -4.52
Index of Refraction -32 ° (C=1, H2O)
Storage condition 2-8°C
Water Solubility 2500 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BP2980000
CHEMICAL NAME :
Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, L-
CAS REGISTRY NUMBER :
541-15-1
LAST UPDATED :
199107
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H15-N-O3
MOLECULAR WEIGHT :
161.23
WISWESSER LINE NOTATION :
OV1YQ1K1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 35,645,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 63,558,1979

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S26-S36-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS BP2980000
HS Code 29239000

 Customs

HS Code 29239000

 Articles155

More Articles
Metabolic and tissue-specific regulation of acyl-CoA metabolism.

PLoS ONE 10(3) , e0116587, (2015)

Acyl-CoA formation initiates cellular fatty acid metabolism. Acyl-CoAs are generated by the ligation of a fatty acid to Coenzyme A mediated by a large family of acyl-CoA synthetases (ACS). Conversely,...

Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis.

World J. Gastroenterol. 20(31) , 10876-85, (2014)

To investigate the beneficial effect of the combination of butyrate, Lactobacillus casei, and L-carnitine in a rat colitis model.Rats were divided into seven groups. Four groups received oral butyrate...

Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.

J. Nutr. 144(12) , 1977-84, (2014)

Biotin functions as a cofactor for several carboxylase enzymes with key roles in metabolism. At present, the dietary requirement for biotin is unknown and intake recommendations are provided as Adequa...

 Synonyms

L-(-)-Carnitine
karnitin
ST 198
EINECS 208-768-0
3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium Hydroxide Inner Salt
Carnitrine
USPorFCC
(R)-Carnitine
Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, L-
L-CARNITIN
3-Hydroxy-4-(trimethylammonio)butanoate
g-Trimethylammonium-b-hydroxybutirate
CAR-OH
Vitamin BT
Monocamin
1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt
(-)-Carnitine
Carnitene
DL-Carnitine
(-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate
carnitine (L-form)
(R)-3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide inner salt
γ-Trimethyl-β-hydroxybutyrobetaine
Carnitine, (-)-
1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (2R)-
(R)-3-hydroxy-4-(trimethylammonio)butanoate
(-)-L-Carnitin
L(-)-Carnitine
Carnitine, L-
3-Hydroxy-4-trimethylammoniobutanoate
UNII:S7UI8SM58A
(L-3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide inner salt
Carnitine DL-form
L-Carnitine
BICARNESINE
Cardiogen
4-Copab
L-Carnitine inner salt
g-Trimethyl-b-hydroxybutyrobetaine
(3R)-3-Hydroxy-4-(trimethylammonio)butanoate
Levocarnitine
g-Amino-b-hydroxybutyric Acid Trimethylbetaine
MFCD00038747
(−)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate
D,L-carnitine
(±)-carnitine
Carniking
carnitine
Carnitor
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