Lucanthone hydrochloride
Modify Date: 2024-01-09 10:54:37
Lucanthone hydrochloride structure
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Common Name | Lucanthone hydrochloride | ||
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| CAS Number | 548-57-2 | Molecular Weight | 376.94 | |
| Density | N/A | Boiling Point | 512.4ºC at 760 mmHg | |
| Molecular Formula | C20H25ClN2OS | Melting Point | 195-196ºC | |
| MSDS | N/A | Flash Point | 263.7ºC | |
Use of Lucanthone hydrochlorideLucanthone hydrochloride is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1). |
| Name | lucanthone hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Lucanthone hydrochloride is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1). |
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| Related Catalog | |
| Target |
APE-1[1] |
| In Vitro | Lucanthone hydrochloride is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone hydrochloride, cell viability is measured by MTT assay. Lucanthone hydrochloride reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone hydrochloride is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC50 of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results[2]. |
| References |
| Boiling Point | 512.4ºC at 760 mmHg |
|---|---|
| Melting Point | 195-196ºC |
| Molecular Formula | C20H25ClN2OS |
| Molecular Weight | 376.94 |
| Flash Point | 263.7ºC |
| Exact Mass | 376.13800 |
| PSA | 60.58000 |
| LogP | 5.35180 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| HS Code | 2932999099 |
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| HS Code | 2932999099 |
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| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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| 1-(2-Diethylamino-ethylamino)-4-methylthiaxanthon,Lucanthon |
| Lycanthone |
| 1-(2-diethylamino-ethylamino)-4-methyl-thioxanthen-9-one,hydrochloride |
| thioxanthone |
| 1-(2-diethylamino-ethylamino)-4-methyl-thioxanthen-9-one |
| 1-<2-Diaethylamino-aethylamino>-4-methyl-thioxanthenon-(9) |
| 1-[[2-(Diethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one |
| 1-(2-Diaethylamino-aethylamino)-4-methyl-thioxanthen-9-on |