Avarol

Modify Date: 2024-01-06 15:47:56

Avarol Structure
Avarol structure
 Common Name Avarol
CAS Number 55303-98-5 Molecular Weight 314.46200
Density 1.055g/cm3 Boiling Point 449.5ºC at 760 mmHg
Molecular Formula C21H30O2 Melting Point N/A
MSDS N/A Flash Point 200ºC

 Use of Avarol


Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling. Avarl also acts as a competitive AChE inhibitor which are non-hepatotoxic and neuroprotective agents for Alzheimer's disease.

 Names

Name 2-[[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]benzene-1,4-diol
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.055g/cm3
Boiling Point 449.5ºC at 760 mmHg
Molecular Formula C21H30O2
Molecular Weight 314.46200
Flash Point 200ºC
Exact Mass 314.22500
PSA 40.46000
LogP 5.43910
Index of Refraction 1.552

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CZ9026700
CHEMICAL NAME :
1,4-Benzenediol, 2-((1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetramethyl- 1-naphthalenyl) methyl)-, (1R-(1-alpha,2-beta,4a-beta,8a-alpha))-
CAS REGISTRY NUMBER :
55303-98-5
LAST UPDATED :
199406
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C21-H30-O2
MOLECULAR WEIGHT :
314.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
269 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Cells - not otherwise specified
DOSE/DURATION :
3800 nmol/L
REFERENCE :
EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 22,473,1986

 Synthetic Route

 Synonyms

Avarol
2-{[(1r,2s,4as,8as)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]methyl}benzene-1,4-diol
(1R-(1alpha,2beta,4abeta,8abeta))-2-((1,2,3,4,4a,7,8,8a-Octahydro-1,2,4a,5-tetramethyl-1-naphthalenyl)methyl)-1,4-benzenediol
Avrol
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