L-alanine

Modify Date: 2024-01-02 15:40:40

L-alanine Structure
L-alanine structure
 Common Name L-alanine
CAS Number 56-41-7 Molecular Weight 89.093
Density 1.2±0.1 g/cm3 Boiling Point 212.9±23.0 °C at 760 mmHg
Molecular Formula C3H7NO2 Melting Point 314.5 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 82.6±22.6 °C

 Use of L-alanine


L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.

 Names

Name L-alanine
Synonym More Synonyms

 L-alanine Biological Activity

Description L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro The viability of both hiPSCs, 201B7 cells and ehiPSCs decrease with an increase in L-Alanine concentration, and reach 7.5±1.3% and 3.7±0.7% respectively at 1.2 M of L-Alanine. On the other hand, no decrease in the viability of hFBs and hSkMCs are observed. Although the viability of iCMs slightly decreases along with the increase of the L-Alanine concentration, viability of iCMs at 1.2 M concentration of L-Alanine, 49.4±6.9%, is significantly higher than that of undifferentiated iPSCs, 201B7 cells and ehiPSCs (p< 0.01). The viability of hiPSCs, 201B7 cells and ehiPSCs, drastically decrease even after 2 or 4 h treatment. In contrast, the viability of hFBs fails to decrease at 1, 2, and 4 h and shows a small decrease at 24 h treatment. The viability of 201B7 cells in suspension culture decreases to 11.8±6.0% following treatment with 1.2 M L-Alanine for 2 h, whereas that of hFBs is 72.9±14.2%[1].
Cell Assay To investigate the selective removal of hiPSCs from differentiated cells by the high L-Alanine medium, two types of hiPSCs, 201B7 hiPSCs (201B7 cells) and an hiPSC line derived by episomal system (ehiPSCs) are used, along with normal human dermal fibroblasts (hFBs), human skeletal muscle cells (hSkMCs) and hiPSC-derived cardiomyocytes (iCMs) as differentiated cells. The cells are incubated in a medium supplemented with L-Alanine at various concentrations (0-1.2 M) or treatment times (1-24 h). The medium is replaced with a normal medium and the relative cell viability is measured after 24 h[1].
References

[1]. Nagashima T, et al. Selective Elimination of Human Induced Pluripotent Stem Cells Using Medium with High Concentration of L-Alanine. Sci Rep. 2018 Aug 20;8(1):12427.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 212.9±23.0 °C at 760 mmHg
Melting Point 314.5 °C (dec.)(lit.)
Molecular Formula C3H7NO2
Molecular Weight 89.093
Flash Point 82.6±22.6 °C
Exact Mass 89.047676
PSA 63.32000
LogP -0.68
Vapour Pressure 0.1±0.9 mmHg at 25°C
Index of Refraction 1.460
Water Solubility 166.5 g/L (25 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY2990000
CHEMICAL NAME :
Alanine, L-
CAS REGISTRY NUMBER :
56-41-7
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C3-H7-N-O2
MOLECULAR WEIGHT :
89.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
50 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 280,279,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81817 No. of Facilities: 290 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 2729 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81817 No. of Facilities: 904 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 18364 (estimated) No. of Female Employees: 14698 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AY2990000
HS Code 2930901000

 Synthetic Route

 Customs

HS Code 2930901000

 Articles216

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 Synonyms

L-ARANINE
MFCD00064410
Fmoc-L-Ala-OH
H-L-ALA-OH
H-ALA-OH
L-ALA
ALANINE
ALA
L-Alanine
Alanin
EINECS 200-273-8
Ritalanine
L-alamine
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