Deoxycorticosterone acetate

Modify Date: 2024-01-02 16:19:37

Deoxycorticosterone acetate structure	Common Name	Deoxycorticosterone acetate
	CAS Number	56-47-3	Molecular Weight	372.498
	Density	1.1±0.1 g/cm3	Boiling Point	504.1±50.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₃₂O₄	Melting Point	157°C
	MSDS	Chinese USA	Flash Point	218.0±30.2 °C

Use of Deoxycorticosterone acetate

Deoxycorticosterone acetate is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone.

Name	21-(acetyloxy)-pregn-4-ene-3,20-dione
Synonym	More Synonyms

Description	Deoxycorticosterone acetate is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor Research Areas >> Endocrinology

Density	1.1±0.1 g/cm3
Boiling Point	504.1±50.0 °C at 760 mmHg
Melting Point	157°C
Molecular Formula	C₂₃H₃₂O₄
Molecular Weight	372.498
Flash Point	218.0±30.2 °C
Exact Mass	372.230072
PSA	60.44000
LogP	4.53
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.542
Storage condition	Refrigerator
Water Solubility	H2O: insoluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HG0525000

CHEMICAL NAME :: 11-Deoxycorticosterone, acetate

CAS REGISTRY NUMBER :: 56-47-3

BEILSTEIN REFERENCE NO. :: 2570798

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C23-H32-O4

MOLECULAR WEIGHT :: 372.55

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A F FV1OV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 520 mg/kg/13W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 83,14,1953 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1258 mg/kg

SEX/DURATION :: male 20 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 28,129,1941

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 316 mg/kg

SEX/DURATION :: female 56 day(s) pre-mating female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 120,238,1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 224 mg/kg

SEX/DURATION :: female 56 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 120,238,1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 16 mg/kg

SEX/DURATION :: male 2 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

REFERENCE :: ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd. Saint-Germain, F-25280 Paris Cedex 06, France) V.1- 1939- Volume(issue)/page/year: 24(Suppl 3),1,1963 *** REVIEWS *** TOXICOLOGY REVIEW CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 17,432,1957 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5546 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 968 (estimated) No. of Female Employees: 494 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	UN 2811
WGK Germany	3
RTECS	HG0525000
Packaging Group	II
Hazard Class	6.1

Precursor 5
CAS#:64-85-7 Desoxycorticosterone CAS#:108-24-7 Ethanoic anhydride CAS#:566-78-9 Pregn-5-en-20-o... CAS#:62490-13-5 3β-formyloxy-21...
CAS#:1171-90-0 Pregna-1,4-dien...
DownStream 7
CAS#:567-02-2 THDOC CAS#:298-36-2 5A-PREGNAN-21-O... CAS#:303-01-5 Pregnane-3,20-d... CAS#:111464-71-2 4,5-epoxy-21-hy...
CAS#:302-97-6 4-Androsten-3-o... CAS#:80-92-2 Pregnane-3,20-d... CAS#:64-85-7 Desoxycorticosterone

Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.

Toxicol. Mech. Methods 18 , 217-27, (2008)

ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifes...

Antibacterial activity of enrofloxacin and ciprofloxacin derivatives of β-octaarginine.

Chem. Biodivers. 12(2) , 179-93, (2015)

β(3) -Octaarginine chains were attached to the functional groups NH and CO2 H of the antibacterial fluoroquinolones ciprofloxacin (→1) and enrofloxacin (→2), respectively, in order to find out whether...

Defensive effect of natrium diethyldithiocarbamate trihydrate (NDDCT) and lisinopril in DOCA-salt hypertension-induced vascular dementia in rats.

Psychopharmacology 223(3) , 307-17, (2012)

Vascular dementia and hypertension are increasing day by day, with a high degree of co-occurrence. Tremendous amount of research work is required so that new pharmacological agents may be identified f...

21-Acetyloxypregn-4-ene-3,20-dione

2-[(8S,9S,10R,13S,14S,17S)-10,13-Dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethylacetat

DOXO

Descotone

Deoxycostone Acetate

2-[(8S,9S,10R,13S,14S,17S)-10,13-Dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl acetate

Pregn-4-ene-3,20-dione, 21- (acetyloxy)-

3,20-Dioxopregn-4-en-21-ylacetat

Desoxycorticosterone acetate (USP)

Doca

Syncort

[2-[(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate

Acétate de 2-[(8S,9S,10R,13S,14S,17S)-10,13-diméthyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tétradécahydro-1H-cyclopenta[a]phénanthrén-17-yl]-2-oxoéthyle

3,20-Dioxopregn-4-en-21-yl acetate

MFCD00003660

EINECS 200-275-9

Pregn-4-ene-3,20-dione, 21-(acetyloxy)-

Deoxycorticosterone acetate