L-Aspartic acid

Modify Date: 2024-01-02 11:14:54

L-Aspartic acid structure	Common Name	L-Aspartic acid
	CAS Number	56-84-8	Molecular Weight	133.103
	Density	1.5±0.1 g/cm3	Boiling Point	264.1±30.0 °C at 760 mmHg
	Molecular Formula	C₄H₇NO₄	Melting Point	>300 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	113.5±24.6 °C

Use of L-Aspartic acid

L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

Name	L-aspartic acid
Synonym	More Synonyms

Description	L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.
Related Catalog	Natural Products >> Others Research Areas >> Cardiovascular Disease
Target	Human Endogenous Metabolite
In Vivo	L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly[1]. L-[3H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[3H]Asp efflux transport. That value for L-[3H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu[2].
References	[1]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406. [2]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11.

Density	1.5±0.1 g/cm3
Boiling Point	264.1±30.0 °C at 760 mmHg
Melting Point	>300 °C (dec.)(lit.)
Molecular Formula	C₄H₇NO₄
Molecular Weight	133.103
Flash Point	113.5±24.6 °C
Exact Mass	133.037506
PSA	100.62000
LogP	-0.67
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.531
Water Solubility	5 g/L (25 ºC)

L-Aspartic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CI9098500

CHEMICAL NAME :: Aspartic acid, L-

CAS REGISTRY NUMBER :: 56-84-8

BEILSTEIN REFERENCE NO. :: 1723530

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C4-H7-N-O4

MOLECULAR WEIGHT :: 133.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25079 mg/kg/7D-C

TOXIC EFFECTS :: Liver - other changes Biochemical - Metabolism (Intermediary) - lipids including transport

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81861 No. of Facilities: 803 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 5939 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81861 No. of Facilities: 634 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 9033 (estimated) No. of Female Employees: 6545 (estimated)

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;Xn: Harmful;
Risk Phrases	R36
Safety Phrases	S26-S24/25-S22
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	CI9098500
HS Code	29224995

Precursor 8
CAS#:110-16-7 Maleic acid CAS#:136083-57-3 Fmoc-D-Asp-OH CAS#:142-42-7 Fumarate CAS#:71989-14-5 FMOC-ASP(OTBU)-OH
CAS#:110-17-8 fumaric acid CAS#:2177-63-1 H-Asp(OBzl)-OH CAS#:108-91-8 Cyclohexylamine CAS#:60342-56-5 disodium 4-hydr...
DownStream 10
CAS#:107208-63-9 H-Asp-Asp-Asp-OH CAS#:1116-15-0 (2S)-2-(octadec... CAS#:1116-12-7 (2S)-2-(decanoy... CAS#:42918-86-5 Z-Abu-OH
CAS#:328-42-7 Oxaloacetic acid CAS#:56-86-0 L-glutamic acid CAS#:302-72-7 DL-Alanine CAS#:4226-18-0 UNII:EU52DFC4WJ
CAS#:32213-95-9 H-Asp(OMe)-OMe.HCl CAS#:16856-13-6 H-Asp(OMe)-OH·HCl

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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asparagic acid

1-amino-1,2-carboxyethane

δ-aspartic acid

d-Asp

QVYZ1VQ &&D or R Form

(-)-Aspartic acid

(2R)-2-Aminosuccinic acid

MFCD00002616

(2R)-2-aminobutanedioic acid

hydrogen D-aspartate

L-Asparticacid

(R)-(−)-Aminosuccinic acid

D-(-)-Aspartic acid

Acide (2R)-2-aminosuccinique

L-Aspartic acid

aspartic acid D-form

Aspartic acid, D-

D-Aspartic acid

H-D-Asp-OH

EINECS 200-291-6

H-Asp-OH

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L-Aspartic acid

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