2-Furoylglycine

Modify Date: 2024-01-10 10:58:25

2-Furoylglycine Structure
2-Furoylglycine structure
 Common Name 2-Furoylglycine
CAS Number 5657-19-2 Molecular Weight 169.13500
Density 1.28g/cm3 Boiling Point 440.6ºC at 760 mmHg
Molecular Formula C7H7NO4 Melting Point 163-165ºC(lit.)
MSDS Chinese USA Flash Point 220.3ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of 2-Furoylglycine


2-Furoylglycine, a urinary metabolite in human, is a putative biomarker for coffee consumption[1].

 Names

Name 2-(furan-2-carbonylamino)acetic acid
Synonym More Synonyms

 2-Furoylglycine Biological Activity

Description 2-Furoylglycine, a urinary metabolite in human, is a putative biomarker for coffee consumption[1].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro 2-Furoylglycine is an intermediate that can be used in the synthesis of non-nucleoside inhibitors of HCV NS5b RNA polymerase[2].
References

[1]. Silke S Heinzmann, et al. 2-Furoylglycine as a Candidate Biomarker of Coffee Consumption. J Agric Food Chem. 2015 Sep 30;63(38):8615-21.

[2]. Stephen S Antonysamy, et al. Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg Med Chem Lett. 2008 May 1;18(9):2990-5.

 Chemical & Physical Properties

Density 1.28g/cm3
Boiling Point 440.6ºC at 760 mmHg
Melting Point 163-165ºC(lit.)
Molecular Formula C7H7NO4
Molecular Weight 169.13500
Flash Point 220.3ºC
Exact Mass 169.03800
PSA 79.54000
LogP 0.48490
Index of Refraction 1.676

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MC0555300
CHEMICAL NAME :
Glycine, N-2-furoyl-
CAS REGISTRY NUMBER :
5657-19-2
BEILSTEIN REFERENCE NO. :
0142378
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H7-N-O4
MOLECULAR WEIGHT :
169.15
WISWESSER LINE NOTATION :
T5OJ BVM1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>7500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 106,406,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
865 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 106,406,1967

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS MC0555300
HS Code 2932190090

 Customs

HS Code 2932190090
Summary 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 Articles3

More Articles
The identification and metabolic origin of 2-furoylglycine and 2,5-furandicarboxylic acid in human urine.

Clin. Chim. Acta 41 , 199-207, (1972)

Metabolism and excretion of [14C]furfural in the rat and mouse.

Food Chem. Toxicol. 32(10) , 887-95, (1994)

The fate of furfural (2-furancarboxaldehyde) was investigated in male and female Fischer 344 (F344) rats given single oral doses of 1, 10 and 60 mg/kg and male and female CD1 mice given 1, 20 and 200 ...

Urinary metabolomic analysis for the identification of renal injury in patients with acute heart failure.

Acad. Emerg. Med. 19(1) , 18-23, (2012)

Worsening renal function in patients admitted with heart failure is associated with increased morbidity. These changes are not usually apparent initially and often take up to 48 hours to be detected. ...

 Synonyms

2-Furoylglycine
GLYCINE,N-2-FUROYL
Furfuroylglycine
Furoylglycine
MFCD00030606
Pyromucuric acid
Glycine,1-furoyl
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