HlyU inhibitor CM14

Modify Date: 2023-01-17 06:30:08

HlyU inhibitor CM14 structure	Common Name	HlyU inhibitor CM14
	CAS Number	588678-13-1	Molecular Weight	345.371
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₁NO₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HlyU inhibitor CM14

HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30; reduces HlyU-dependent expression of virulence genes in V. vulnificus. In addition to the decreased hemolysis of human erythrocytes without affecting bacterial growth or triggering the host cell death; also reduces HlyU-dependent expression of virulence genes in V. vulnificus, decreases the expression of various virulence genes of other Vibrio species and thus attenuates their virulence phenotypes.

Name	N-(4-Oxo-4H-thieno[3,4-c]chromen-3-yl)-3-phenyl-2-propynamide
Synonym	More Synonyms

Description	HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30; reduces HlyU-dependent expression of virulence genes in V. vulnificus. In addition to the decreased hemolysis of human erythrocytes without affecting bacterial growth or triggering the host cell death; also reduces HlyU-dependent expression of virulence genes in V. vulnificus, decreases the expression of various virulence genes of other Vibrio species and thus attenuates their virulence phenotypes.
References	References 1. Lee ZW, et al. Sci Rep. 2019 Mar 13;9(1):4346. doi: 10.1038/s41598-019-39554-y. View Related Products by Target Other Targets

Description

References

References 1. Lee ZW, et al. Sci Rep. 2019 Mar 13;9(1):4346. doi: 10.1038/s41598-019-39554-y. View Related Products by Target Other Targets