tolazoline

Modify Date: 2024-01-05 17:18:18

tolazoline structure	Common Name	tolazoline
	CAS Number	59-98-3	Molecular Weight	160.216
	Density	1.1±0.1 g/cm3	Boiling Point	338.2±21.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₂N₂	Melting Point	66-69 °C(lit.)
	MSDS	N/A	Flash Point	158.3±22.1 °C

Use of tolazoline

Tolazoline(NSC35110; Imidaline) is a non-selective competitive α-adrenergic receptor antagonist.IC50 value:Target: α-adrenoceptor antagonistTolazoline can be synthesized by the heterocyclation of the ethyl ester of iminophenzylacetic acid with ethylene diamine, which forms the desired product. The structure of tolazoline is strikingly similar to α-adrenergic agonists, which are antiedema sympathomimetics.

Name	tolazoline
Synonym	More Synonyms

Description	Tolazoline(NSC35110; Imidaline) is a non-selective competitive α-adrenergic receptor antagonist.IC50 value:Target: α-adrenoceptor antagonistTolazoline can be synthesized by the heterocyclation of the ethyl ester of iminophenzylacetic acid with ethylene diamine, which forms the desired product. The structure of tolazoline is strikingly similar to α-adrenergic agonists, which are antiedema sympathomimetics.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Others
References	[1]. Tolazoline, From Wikipedia

Density	1.1±0.1 g/cm3
Boiling Point	338.2±21.0 °C at 760 mmHg
Melting Point	66-69 °C(lit.)
Molecular Formula	C₁₀H₁₂N₂
Molecular Weight	160.216
Flash Point	158.3±22.1 °C
Exact Mass	160.100052
PSA	24.39000
LogP	2.65
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.596

tolazoline MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ1925000

CHEMICAL NAME :: 2-Imidazoline, 2-benzyl-

CAS REGISTRY NUMBER :: 59-98-3

BEILSTEIN REFERENCE NO. :: 0128757

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H12-N2

MOLECULAR WEIGHT :: 160.24

WISWESSER LINE NOTATION :: T5M CN BUTJ B1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 62500 ug/L

REFERENCE :: GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981

Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22;R36/37/38
Safety Phrases	S26-S28-S36/37/39-S45
WGK Germany	3
RTECS	NJ1925000
HS Code	2933290090

Precursor 10
CAS#:107-15-3 1,2-Ethanediamine CAS#:645-54-5 2-Phenylethanet... CAS#:140-29-4 Benzyl cyanide CAS#:103-82-2 Phenylacetic acid
CAS#:122-78-1 Phenylacetaldehyde CAS#:1011736-08-5 N-nitroso-2-ben... CAS#:7218-04-4 Ac-DL-Cys-OH CAS#:5467-51-6 (5Z)-5-(1H-indo...
CAS#:7436-90-0 (2,2-Dibromovin... CAS#:5442-34-2 Benzeneethanimi...
DownStream 3
CAS#:65248-65-9 2-benzyl-1-meth... CAS#:63226-76-6 N-(2-acetamidoe... CAS#:122-78-1 Phenylacetaldehyde

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Benzidazol

Tolazolin

2-benzyl-4,5-diyhdroimidazole

2-Benzyl-4,5-dihydro-1H-imidazole

Priscol

EINECS 200-448-9

2-(phenylmethyl)-4,5-dihydro-1H-imidazole

Prefaxil

1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-

2-benzyl-2-imidazoline

tolazoline

Imidalin

MFCD00005182

2-Benzyl-4,5-dihydroimidazole

Divascol

2-Benzylimidazoline

Olitensol

Priscoline

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: tolazoline
Price: Click To Check
Purity: 97.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: tolazoline
Price: ￥848.0/5g
Purity: 99.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Tolazoline
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Tolazoline
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥305.5/1g

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tolazoline

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