GL-1196
Modify Date: 2024-01-09 18:59:17
GL-1196 structure
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Common Name | GL-1196 | ||
|---|---|---|---|---|
| CAS Number | 591242-70-5 | Molecular Weight | 398.863 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 626.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C20H15ClN2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 332.6±34.3 °C | |
Use of GL-1196GL-1196 is a PAK4 inhibitor that effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclinD1 pathway and CDK4/6 expression; prominently inhibits the invasion of human gastric cancer cells in parallel with blockage of the PAK4/LIMK1/cofilin pathway; also inhibits the formation of filopodia and induced cell elongation in SGC7901 and BGC823 cells. |
| Name | 2-{[(4-Chlorophenyl)(1,1-dioxido-1,2-benzothiazol-3-yl)amino]methyl}phenol |
|---|---|
| Synonym | More Synonyms |
| Description | GL-1196 is a PAK4 inhibitor that effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclinD1 pathway and CDK4/6 expression; prominently inhibits the invasion of human gastric cancer cells in parallel with blockage of the PAK4/LIMK1/cofilin pathway; also inhibits the formation of filopodia and induced cell elongation in SGC7901 and BGC823 cells. |
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| References | References 1. Zhang J, et al. Int J Mol Sci. 2016 Apr 11;17(4):470. View Related Products by Target p21-activated Kinase (PAK) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 626.4±65.0 °C at 760 mmHg |
| Molecular Formula | C20H15ClN2O3S |
| Molecular Weight | 398.863 |
| Flash Point | 332.6±34.3 °C |
| Exact Mass | 398.049194 |
| LogP | 4.01 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.679 |
| Phenol, 2-[[(4-chlorophenyl)(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]methyl]- |
| 2-{[(4-Chlorophenyl)(1,1-dioxido-1,2-benzothiazol-3-yl)amino]methyl}phenol |
| MFCD04084648 |