8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol structure
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Common Name | 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol | ||
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CAS Number | 59468-85-8 | Molecular Weight | 341.76700 | |
Density | 1.44g/cm3 | Boiling Point | 550.6ºC at 760 mmHg | |
Molecular Formula | C18H13ClFN3O | Melting Point | 186-187ºC | |
MSDS | USA | Flash Point | 286.8ºC |
Name | 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol |
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Synonym | More Synonyms |
Density | 1.44g/cm3 |
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Boiling Point | 550.6ºC at 760 mmHg |
Melting Point | 186-187ºC |
Molecular Formula | C18H13ClFN3O |
Molecular Weight | 341.76700 |
Flash Point | 286.8ºC |
Exact Mass | 341.07300 |
PSA | 50.41000 |
LogP | 3.25070 |
Index of Refraction | 1.688 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |
~% 8-chloro-6-(2-f... CAS#:59468-85-8 |
Literature: Xenobiotica, , vol. 32, # 11 p. 975 - 984 |
~% 8-chloro-6-(2-f... CAS#:59468-85-8 |
Literature: Xenobiotica, , vol. 38, # 4 p. 353 - 367 |
Precursor 1 | |
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DownStream 1 | |
A comparison of the metabolism of midazolam in C57BL/6J and hepatic reductase null (HRN) mice.
Biochem. Pharmacol. 92(4) , 701-11, (2014) The hepatic cytochrome P450 reductase null (HRN) mouse, which has no functional hepatic Cyp P450s, may represent a useful model for examining extra-hepatic P450-related oxidative metabolism. Here the ... |
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Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.
J. Chromatogr. A. 1374 , 122-33, (2014) The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicab... |
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Species differences and substrate specificity of CYP3A heteroactivation by efavirenz.
Xenobiotica 45(4) , 345-52, (2015) 1. The purpose of this study was to clarify species differences in the heteroactivation of CYP3A substrates by efavirenz, which is known from clinical studies to activate midazolam 1'-hydroxylation, a... |
8-Chloro-6-(2-fluorophenyl)-4-hydroxy-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine |
8-Chloro-6-(2-fluorophenyl)-4-hydroxy-4H-imidazo[1,5a][1,4]bezodiazepine |
4-OH-Mdz |
4-hydroxy-MDZ |
8-chloro-(2-fluoro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-4-ol |
4-Hydroxy Midazolam |