Arecaidine hydrochloride

Modify Date: 2024-01-03 12:35:53

Arecaidine hydrochloride structure	Common Name	Arecaidine hydrochloride
	CAS Number	6018-28-6	Molecular Weight	177.62900
	Density	N/A	Boiling Point	266.7ºC at 760 mmHg
	Molecular Formula	C₇H₁₂ClNO₂	Melting Point	260ºC
	MSDS	N/A	Flash Point	115.1ºC

Use of Arecaidine hydrochloride

Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].

Name	Arecaidine hydrochloride
Synonym	More Synonyms

Description	Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
References	[1]. D Lodge, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22. [2]. Valerie Voigt, et al. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). J Pharm Pharmacol. 2013 Apr;65(4):582-90.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

References

[1]. D Lodge, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22.

[2]. Valerie Voigt, et al. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). J Pharm Pharmacol. 2013 Apr;65(4):582-90.

Boiling Point	266.7ºC at 760 mmHg
Melting Point	260ºC
Molecular Formula	C₇H₁₂ClNO₂
Molecular Weight	177.62900
Flash Point	115.1ºC
Exact Mass	177.05600
PSA	40.54000
LogP	1.07280
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT2087000

CHEMICAL NAME :: Nicotinic acid, 1,2,5,6-tetrahydro-1-methyl-, hydrochloride

CAS REGISTRY NUMBER :: 6018-28-6

LAST UPDATED :: 199007

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H11-N-O2.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year: 113,123,1969

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
WGK Germany	3
RTECS	QT2087000
HS Code	2933399090

3-Pyridinecarbo...

CAS#:61-94-9

~66%

Arecaidine hydr...

CAS#:6018-28-6

Literature: Martin, Arnold R.; Paradkar, Vidyadhar M.; Peng, Geoffrey W.; Speth, Robert C.; Yamamura, Henry I.; Horn, Alan S. Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 865 - 873

Arecoline hydro...

CAS#:300-08-3

Arecaidine hydr...

CAS#:6018-28-6

Literature: WO2013/184757 A1, ; Page/Page column 108 ;

Precursor 2
CAS#:61-94-9 3-Pyridinecarbo... CAS#:300-08-3 Arecoline hydro...
DownStream 1
CAS#:5657-70-5 1-methylpiperid...

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid,hydrochloride

MFCD00051993

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