GNF-1331
Modify Date: 2024-07-22 10:25:18
GNF-1331 structure
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Common Name | GNF-1331 | ||
|---|---|---|---|---|
| CAS Number | 603101-22-0 | Molecular Weight | 440.542 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C20H20N6O2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GNF-1331GNF-1331 is a Potent, Selective, and Orally Bioavailable Porcupine Inhibitor (IC50 = 12 nM). Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. Wnt signaling is tightly controlled during cellular proliferation, differentiation, and embryonic morphogenesis. Aberrant activation of this pathway plays a critical role in a variety of cancers, such as cutaneous squamous cell carcinoma (SCC), breast cancer, and colorectal cancer. |
| Name | gnf-1331 |
|---|---|
| Synonym | More Synonyms |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H20N6O2S2 |
| Molecular Weight | 440.542 |
| Exact Mass | 440.108917 |
| LogP | 4.35 |
| Index of Refraction | 1.724 |
| MFCD03750964 |
| Acetamide, N-(6-methoxy-2-benzothiazolyl)-2-[[4-propyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]- |
| gnf-1331 |
| N-(6-Methoxy-1,3-benzothiazol-2-yl)-2-{[4-propyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide |
| N-(6-Methoxy-2-benzothiazolyl)-2-[[4-propyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-acetamide |