4,4'-Bi-o-toluidine dihydrochloride

Modify Date: 2024-01-02 18:36:56

4,4'-Bi-o-toluidine dihydrochloride Structure
4,4'-Bi-o-toluidine dihydrochloride structure
Common Name 4,4'-Bi-o-toluidine dihydrochloride
CAS Number 612-82-8 Molecular Weight 285.212
Density N/A Boiling Point 361ºC at 760 mmHg
Molecular Formula C14H18Cl2N2 Melting Point >300°C
MSDS Chinese USA Flash Point N/A
Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09
Signal Word Danger

 Names

Name 3,3'-Dimethylbenzidine dihydrochloride
Synonym More Synonyms

 Chemical & Physical Properties

Boiling Point 361ºC at 760 mmHg
Melting Point >300°C
Molecular Formula C14H18Cl2N2
Molecular Weight 285.212
Exact Mass 284.084717
PSA 52.04000
LogP 5.90120

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD1226000
CHEMICAL NAME :
Benzidine, 3,3'-dimethyl-, dihydrochloride
CAS REGISTRY NUMBER :
612-82-8
LAST UPDATED :
199709
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C14-H16-N2.2Cl-H
MOLECULAR WEIGHT :
285.24
WISWESSER LINE NOTATION :
ZR B1 DR DZ C1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1120 mg/kg/14D-C
TOXIC EFFECTS :
Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18200 mg/kg/13W-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified) Blood - changes in erythrocyte (RBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1820 mg/kg/65W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15288 mg/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
20 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-390,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1372 No. of Facilities: 132 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 1178 (estimated) No. of Female Employees: 105 (estimated)

 Safety Information

Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09
Signal Word Danger
Hazard Statements H302-H350-H411
Precautionary Statements P201-P273-P301 + P312 + P330-P308 + P313-P391-P501
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T:Toxic;N:Dangerousfortheenvironment;
Risk Phrases R22;R45;R51/53;R68
Safety Phrases S53-S45-S61
RIDADR UN 3077 9/PG 3
WGK Germany 3
RTECS DD1226000
Packaging Group III
Hazard Class 6.1(b)

 Precursor & DownStream

Precursor  0

DownStream  1

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 Synonyms

(1,1'-Biphenyl)-4,4'-diamine, 3,3'-dimethyl-, dihydrochloride
O-TOLIDINE HYDROCHLORIDE
3,3'-Dimethyl-[1,1'-biphenyl]-4,4'-diamine dihydrochloride
8-Piperazin-1-yl-quinoline
MFCD00012960
3,3'-Dimethyl-4,4'-biphenyldiamine dihydrochloride
3,3'-Dimethyl-benzidin,Dihydrochlorid
o-Tolidine dihydroch
3,3'-Dimethylbiphenyl-4,4'-diamine dihydrochloride
Benzidine, 3,3'-dimethyl-, dihydrochloride
[1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethyl-, dihydrochloride
3,3′-Dimethylbenzidine dihydrochloride
3,3'-dimethyl-benzidine,dihydrochloride
3,3'-dimethylbenzidine diammonium chloride
O-TolidineHydrochlorideGr
EINECS 210-322-5
o-Tolidine2HCl
THALLIUM ARSENATE
O-TOLIDINE DI HCL
4,4'-Bi-o-toluidine dihydrochloride
[1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethyl-, hydrochloride (1:2)
3,3'-Dimethylbenzidine dihydrochloride
4,4′-Diamino-3,3′-dimethylbiphenyl dihydrochloride
3,3'-Dimethyl-4,4'-diaminobiphenyl dihydrochloride
O-TOLIDINE DIHYDROCHLORIDE
ZR B1 DR DZ C1 &&2HCl