4-Androsten-4-ol-3,17-dione acetate

Modify Date: 2024-01-02 12:19:29

4-Androsten-4-ol-3,17-dione acetate structure	Common Name	4-Androsten-4-ol-3,17-dione acetate
	CAS Number	61630-32-8	Molecular Weight	344.44500
	Density	1.18g/cm3	Boiling Point	501.2ºC at 760 mmHg
	Molecular Formula	C₂₁H₂₈O₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	219.2ºC

Name	4-Androsten-4-ol-3,17-dione acetate
Synonym	More Synonyms

Density	1.18g/cm3
Boiling Point	501.2ºC at 760 mmHg
Molecular Formula	C₂₁H₂₈O₄
Molecular Weight	344.44500
Flash Point	219.2ºC
Exact Mass	344.19900
PSA	60.44000
LogP	3.97820
Index of Refraction	1.548

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8153000

CHEMICAL NAME :: Androst-4-ene-3,17-dione, 4-hydroxy-, acetate (ester)

CAS REGISTRY NUMBER :: 61630-32-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H28-O4

MOLECULAR WEIGHT :: 344.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 300 mg/kg

SEX/DURATION :: female 2-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 18,365,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 375 mg/kg

SEX/DURATION :: female 18 day(s) pre-mating female 1-8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 18,365,1978

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
RTECS	BV8153000

Formestane

CAS#:566-48-3

Acetyl chloride

CAS#:75-36-5

~97%

4-Androsten-4-o...

CAS#:61630-32-8

Literature: Andrade; Paixao; De Almeida; Fernandes Roleira; Tavares Da Silva Acta Crystallographica Section C: Crystal Structure Communications, 2007 , vol. 63, # 6 p. o330-o331

Ethanoic anhydride

CAS#:108-24-7

Formestane

CAS#:566-48-3

~66%

4-Androsten-4-o...

CAS#:61630-32-8

Literature: Marsh, David A.; Brodie, Harry J.; Garrett, Wesley; Tsai-Morris, Chon-Hwa; Brodie, Angela M. H. Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 788 - 795

4,5-epoxyandros...

CAS#:77057-73-9

4-Androsten-4-o...

CAS#:61630-32-8

Literature: Mann, John; Pietrzak, Barbara Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2681 - 2685

Formestane

CAS#:566-48-3

Acetylsalicyloy...

CAS#:5538-51-2

4-(O-acetylsali...

CAS#:1373116-44-9

4-Androsten-4-o...

CAS#:61630-32-8

Literature: Varela, Carla; Tavares Da Silva, Elisiario J.; Amaral, Cristina; Correia Da Silva, Georgina; Baptista, Teresa; Alcaro, Stefano; Costa, Giosue; Carvalho, Rui A.; Teixeira, Natercia A. A.; Roleira, Fernanda M. F. Journal of Medicinal Chemistry, 2012 , vol. 55, # 8 p. 3992 - 4002

Ethanoic anhydride

CAS#:108-24-7

5-α-fluoro-4α-h...

CAS#:66880-12-4

4-Androsten-4-o...

CAS#:61630-32-8

Literature: Mann, John; Pietrzak, Barbara Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2681 - 2685

Precursor 6
CAS#:566-48-3 Formestane CAS#:75-36-5 Acetyl chloride CAS#:108-24-7 Ethanoic anhydride CAS#:77057-73-9 4,5-epoxyandros...
CAS#:5538-51-2 Acetylsalicyloy... CAS#:66880-12-4 5-α-fluoro-4α-h...
DownStream 0

Aromatase inhibitors and the treatment of breast cancer.

J. Steroid Biochem. 24 , 91, (1986)

Inhibition of aromatase to reduce estrogen production by peripheral and ovarian tissue could be a useful approach to treating hormone-dependent breast cancer. Several C19, 17 keto steroids have been i...

Inhibition of estrogen biosynthesis and regression of mammary tumors by aromatase inhibitors.

Adv. Exp. Med. Biol. 138 , 179-90, (1981)

Overview of recent development of aromatase inhibitors.

Cancer Res. 42(8 Suppl) , 3312s-3314s, (1982)

Since the first publication in 1973 concerning aromatase inhibitors, several effective compounds have been reported by a number of investigators. Our studies with 4-hydroxyandrostene-3,17-dione, 4-ace...

[(8R,9S,10R,13S,14S)-10,13-dimethyl-3,17-dioxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-4-yl] acetate

4-Androsten-4-ol-3,17-dione acetate

Names

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Articles14

Synonyms