O-Desmethyl Metoprolol

Modify Date: 2024-01-06 20:14:15

O-Desmethyl Metoprolol Structure
O-Desmethyl Metoprolol structure
Common Name O-Desmethyl Metoprolol
CAS Number 62572-94-5 Molecular Weight 253.33700
Density 1.085g/cm3 Boiling Point 424.6ºC at 760 mmHg
Molecular Formula C14H23NO3 Melting Point 70-72ºC
MSDS Chinese USA Flash Point 210.6ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of O-Desmethyl Metoprolol


O-Desmethyl metoprolol is the major active metabolite of the β1-adrenergic receptor blocker metoprolol.

 Names

Name O-Desmethyl Metoprolol
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.085g/cm3
Boiling Point 424.6ºC at 760 mmHg
Melting Point 70-72ºC
Molecular Formula C14H23NO3
Molecular Weight 253.33700
Flash Point 210.6ºC
Exact Mass 253.16800
PSA 61.72000
LogP 1.35000
Index of Refraction 1.531

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DA0512150
CHEMICAL NAME :
Benzeneethanol, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-
CAS REGISTRY NUMBER :
62572-94-5
LAST UPDATED :
198809
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H23-N-O3
MOLECULAR WEIGHT :
253.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,186,1979

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
RIDADR NONH for all modes of transport
RTECS DA0512150

 Articles1

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Identification of transformation products from β-blocking agents formed in wetland microcosms using LC-Q-ToF.

J. Mass Spectrom. 51 , 207-18, (2016)

Identification of degradation products from trace organic compounds, which may retain the biological activity of the parent compound, is an important step in understanding the long-term effects of the...

 Synonyms

1-[4-(2-hydroxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol