2-Chloro-5-nitroaniline

Modify Date: 2024-01-05 13:13:12

2-Chloro-5-nitroaniline structure	Common Name	2-Chloro-5-nitroaniline
	CAS Number	6283-25-6	Molecular Weight	172.569
	Density	1.5±0.1 g/cm3	Boiling Point	314.6±22.0 °C at 760 mmHg
	Molecular Formula	C₆H₅ClN₂O₂	Melting Point	118-120 °C(lit.)
	MSDS	Chinese USA	Flash Point	144.1±22.3 °C
	Symbol	GHS06, GHS08, GHS09	Signal Word	Danger

Name	2-Chloro-5-nitro-benzamine
Synonym	More Synonyms

Density	1.5±0.1 g/cm3
Boiling Point	314.6±22.0 °C at 760 mmHg
Melting Point	118-120 °C(lit.)
Molecular Formula	C₆H₅ClN₂O₂
Molecular Weight	172.569
Flash Point	144.1±22.3 °C
Exact Mass	172.003952
PSA	71.84000
LogP	2.40
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.646

2-Chloro-5-nitroaniline MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BX1500000

CHEMICAL NAME :: Aniline, 2-chloro-5-nitro-

CAS REGISTRY NUMBER :: 6283-25-6

BEILSTEIN REFERENCE NO. :: 2208878

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C6-H5-Cl-N2-O2

MOLECULAR WEIGHT :: 172.58

WISWESSER LINE NOTATION :: ZR BG ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2015 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness

REFERENCE :: TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 206512

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 206512

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 206512

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 206512

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03227 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12660 mg/kg/15D-C

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Blood - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570907

Symbol	GHS06, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H300-H310-H330-H373-H411
Precautionary Statements	P260-P264-P273-P280-P284-P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+:Verytoxic;N:Dangerous for the environment;
Risk Phrases	R26/27/28;R33;R51/53
Safety Phrases	S28-S36/37-S45-S61-S28A
RIDADR	UN 2237 6.1/PG 3
WGK Germany	3
RTECS	BX1500000
Packaging Group	III
Hazard Class	6.1
HS Code	2921420090

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DownStream 10
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HS Code	2921420090
Summary	HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Determination of trace level genotoxic impurities in small molecule drug substances using conventional headspace gas chromatography with contemporary ionic liquid diluents and electron capture detection.

J. Chromatogr. A. 1361 , 217-28, (2014)

Ionic liquids (ILs) were used as a new class of diluents for the analysis of two classes of genotoxic impurities (GTIs), namely, alkyl/aryl halides and nitro-aromatics, in small molecule drug substanc...

MFCD00007668

2-Chloro-5-nitroaniline

Benzenamine, 2-chloro-5-nitro-

EINECS 228-498-7