Balanol
Modify Date: 2024-01-03 11:12:47
Balanol structure
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Common Name | Balanol | ||
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| CAS Number | 63590-19-2 | Molecular Weight | 550.51300 | |
| Density | 1.62g/cm3 | Boiling Point | 935.9ºC at 760 mmHg | |
| Molecular Formula | C28H26N2O10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 519.8ºC | |
Use of BalanolBalanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC50s=4-9 nM) and ζ (IC50=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides[1][2]. |
| Name | (4Z)-4-[(2-carboxy-6-hydroxyphenyl)-hydroxymethylidene]-3-hydroxy-1-[(3R,4R)-3-[(4-hydroxybenzoyl)amino]-2,3,4,5-tetrahydro-1H-azepin-4-yl]-5-oxocyclohex-2-ene-1-carboxylic acid |
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| Synonym | More Synonyms |
| Description | Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC50s=4-9 nM) and ζ (IC50=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides[1][2]. |
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| Related Catalog | |
| Target |
Human PKCα:4-9 nM () PKC-βI:4-9 nM () PKC-βII:4-9 nM () Human PKCγ:4-9 nM () Human PKCδ:4-9 nM () Human PKCε:4-9 nM () human PKCη:150 nM () PKA |
| In Vitro | Balanol (3 μM; 45 min) 抑制 PKA，表现为抑制异丙肾上腺素 (HY-B0468) 对新生大鼠肌细胞A431中荧光素酶活性的诱导作用[1]。 Balanol (10 μM; 45 min) 抑制 A431 细胞中 CREB 和 MARCKS 的磷酸化[1]。 |
| References |
| Density | 1.62g/cm3 |
|---|---|
| Boiling Point | 935.9ºC at 760 mmHg |
| Molecular Formula | C28H26N2O10 |
| Molecular Weight | 550.51300 |
| Flash Point | 519.8ºC |
| Exact Mass | 550.15900 |
| PSA | 202.72000 |
| LogP | 2.86530 |
| Index of Refraction | 1.746 |
| Benzoic acid,4-(2-(((hexahydro-4-((4-hydroxybenzoyl)oxy)-1H-azepin-3-yl)amino)carbonyl)-6-hydroxybenzoyl)-3,5-dihydroxy |
| Ophiocordin |