CAY10580
Modify Date: 2024-01-10 19:19:39
CAY10580 structure
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Common Name | CAY10580 | ||
|---|---|---|---|---|
| CAS Number | 64054-40-6 | Molecular Weight | 341.49 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 534.4±25.0 °C at 760 mmHg | |
| Molecular Formula | C19H35NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 277.0±23.2 °C | |
Use of CAY10580CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM)[1]. |
| Name | 7-[2-(3-hydroxyoctyl)-5-oxopyrrolidin-1-yl]heptanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM)[1]. |
|---|---|
| Related Catalog | |
| Target |
EP4:35 nM (Ki) EP4 Receptor:35 nM (Ki) EP2 Receptor:3000 nM (Ki) EP3 receptor:2000 nM (Ki) |
| In Vitro | CAY10580 (10-10000 nM; 40 min) significantly increases apical membrane abundance of AQP2 in MDCK cells at 100 to 10000 nM[2]. |
| In Vivo | CAY10580 (200 μg/kg body weight; i.p; daily for three weeks) effectively prevents diet-induced hypercholesterolemia, enhances endogenous bile acid synthesis and their fecal excretion[3]. Animal Model: Six-week old male EP4+/+ mice (Treating high fat diet-challenged mice)[3] Dosage: 200 μg/kg body weight Administration: Intraperitoneal injection; daily for remaining three weeks Result: High fat diet fed mice exhibited lower total cholesterol levels compared to the vehicle group by 28.5%. Total cholesterol levels decreased from 137.4 to 98.2 mg/dl, restoring plasma cholesterol back to near-normal values. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 534.4±25.0 °C at 760 mmHg |
| Molecular Formula | C19H35NO4 |
| Molecular Weight | 341.49 |
| Flash Point | 277.0±23.2 °C |
| Exact Mass | 341.256622 |
| PSA | 77.84000 |
| LogP | 2.88 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.494 |
| 7-[2-(3-Hydroxyoctyl)-5-oxo-1-pyrrolidinyl]heptanoic acid |
| 1-Pyrrolidineheptanoic acid, 2-(3-hydroxyoctyl)-5-oxo- |