Barbinervic acid

Modify Date: 2024-04-03 21:37:01

Barbinervic acid Structure
Barbinervic acid structure
Common Name Barbinervic acid
CAS Number 64199-78-6 Molecular Weight 488.70
Density 1.2±0.1 g/cm3 Boiling Point 622.8±55.0 °C at 760 mmHg
Molecular Formula C30H48O5 Melting Point 278-280 ºC
MSDS N/A Flash Point 344.5±28.0 °C

 Use of Barbinervic acid


Barbinervic acid is a glutaminase inhibitor with an IC50 of 14 μM. Barbinervic acid can be used for the study of neurodegenerative diseases[1].

 Names

Name (1R,2R,4aS,6aS,6bR,8aR,9S,10R,12aR,12bR,14bS)-1,10-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
Synonym More Synonyms

 Barbinervic acid Biological Activity

Description Barbinervic acid is a glutaminase inhibitor with an IC50 of 14 μM. Barbinervic acid can be used for the study of neurodegenerative diseases[1].
Related Catalog
References

[1]. Atsumi Shimada, et al. Pentacyclic triterpene acids, rotungenic acid and barbinervic acid, from fresh leaves of Diospyros kaki Thunberg and their glutaminase inhibitory activities. Nat Prod Res. 2022 Nov 26;1-5.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 622.8±55.0 °C at 760 mmHg
Melting Point 278-280 ºC
Molecular Formula C30H48O5
Molecular Weight 488.70
Flash Point 344.5±28.0 °C
Exact Mass 488.350189
PSA 97.99000
LogP 5.75
Vapour Pressure 0.0±4.1 mmHg at 25°C
Index of Refraction 1.581
Water Solubility Insuluble (1.8E-3 g/L) (25 ºC)

 Safety Information

Hazard Codes Xi

 Synonyms

(3α)-3,19,24-Trihydroxyurs-12-en-28-oic acid
Urs-12-en-28-oic acid, 3,19,24-trihydroxy-, (3α)-
Barbinervic acid