Alstonine

Modify Date: 2024-01-08 13:34:28

Alstonine Structure
Alstonine structure
Common Name Alstonine
CAS Number 642-18-2 Molecular Weight 348.41
Density 0.9±0.1 g/cm3 Boiling Point 189.9±0.0 °C at 760 mmHg
Molecular Formula C21H20N2O3 Melting Point N/A
MSDS N/A Flash Point 65.0±8.0 °C

 Use of Alstonine


Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties[1].

 Names

Name Propoxybenzene
Synonym More Synonyms

 Alstonine Biological Activity

Description Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties[1].
Related Catalog
In Vitro Alstonine has the capacity to distinguish cancer DNA from healthy tissue DNA; it inhibits DNA in vitro synthesis when DNA from different cancerous tissues or cells is used as template. Practically without effects on DNA from healthy tissues[1].
In Vivo In mice models Alstonine shows a clear, dose-dependent, potent antipsychotic profile. Alstonine (i.p.) prevents amphetamine-induced lethality, with active doses within the range of 0.5-2.0 mg/kg[1]. Alstonine (0.1, 0.5 and 1.0 mg/kg) prevents MK-801 induced hyperlocomotion. Because Alstonine partially reverses MK-801-induced increase in locomotion both at the hole-board and locomotor activity cages[1]. Alstonine successfully treats a relatively important proportion of BALB/C mice inoculated with transplantable YC8 lymphoma ascites cells as well as Swiss mice bearing Ehrlich ascites carcinoma cells[1].
References

[1]. E Elisabetsky, et al. The Alkaloid Alstonine: A Review of Its Pharmacological Properties. Evid Based Complement Alternat Med. 2006 Mar;3(1):39-48.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 189.9±0.0 °C at 760 mmHg
Molecular Formula C21H20N2O3
Molecular Weight 348.41
Flash Point 65.0±8.0 °C
LogP 3.20
Vapour Pressure 0.8±0.3 mmHg at 25°C
Index of Refraction 1.488

 Safety Information

Hazard Codes Xi

 Synonyms

Benzene, propoxy-
phenylether
Propoxybenzene
PHENYL PROPYL ETHER
Alstonine
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