Glycoursodeoxycholic acid

Modify Date: 2024-01-02 13:06:17

Glycoursodeoxycholic acid structure	Common Name	Glycoursodeoxycholic acid
	CAS Number	64480-66-6	Molecular Weight	449.62300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₄₃NO₅	Melting Point	232-235ºC
	MSDS	Chinese USA	Flash Point	N/A

Use of Glycoursodeoxycholic acid

Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.In Vitro: The antioxidant compound glycoursodeoxycholic acid (GUDCA) fully abrogates UCB-induced cytochrome c oxidase inhibition and significantly prevents oxidative stress, metabolic alterations, and cell demise[1].GUDCA has shown therapeutic efficacy in neurodegenerative models and diseases. Increased cytosolic SOD1 inclusions were observed in 4 DIV NSC-34/hSOD1(G93A) cells together with decreased mitochondria viability, caspase-9 activation, and apoptosis[2]. Glycoursodeoxycholic acid shows preventive and restorative effects against unconjugated bilirubin -induced blood-brain barrier disruption and damage to human brain microvascular endothelial cells[3].

Name	Glycoursodeoxycholic acid
Synonym	More Synonyms

Description	Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.In Vitro: The antioxidant compound glycoursodeoxycholic acid (GUDCA) fully abrogates UCB-induced cytochrome c oxidase inhibition and significantly prevents oxidative stress, metabolic alterations, and cell demise[1].GUDCA has shown therapeutic efficacy in neurodegenerative models and diseases. Increased cytosolic SOD1 inclusions were observed in 4 DIV NSC-34/hSOD1(G93A) cells together with decreased mitochondria viability, caspase-9 activation, and apoptosis[2]. Glycoursodeoxycholic acid shows preventive and restorative effects against unconjugated bilirubin -induced blood-brain barrier disruption and damage to human brain microvascular endothelial cells[3].
Related Catalog	Natural Products >> Alkaloid Research Areas >> Neurological Disease

Description

Related Catalog

Natural Products >> Alkaloid

Research Areas >> Neurological Disease

Melting Point	232-235ºC
Molecular Formula	C₂₆H₄₃NO₅
Molecular Weight	449.62300
Exact Mass	449.31400
PSA	106.86000
LogP	3.98500
Storage condition	-20°C Freezer

RIDADR	NONH for all modes of transport

Ultra high resolution SFC-MS as a high throughput platform for metabolic phenotyping: application to metabolic profiling of rat and dog bile.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 966 , 200-7, (2014)

Ultra high resolution SFC-MS (on sub-2μm particles) coupled to mass spectrometry has been evaluated for the metabolic profiling of rat and dog bile. The selectivity of the SFC separation differed from...

A possible role of chenodeoxycholic acid and glycine-conjugated bile acids in fibrotic steatohepatitis in a dietary rat model.

Dig. Dis. Sci. 59(7) , 1490-501, (2014)

Our previous study indicated that hepatic bile acids (BAs) may have deposited and stimulated the pathogenesis of a high fat-cholesterol (HFC) diet-induced fibrotic steatohepatitis in stroke-prone spon...

A liquid chromatography-tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids.

J. Chromatogr. A. 1371 , 184-95, (2014)

Recently, hydroxy sterols and bile acids have gained growing interest as they are important regulators of energy homoeostasis and inflammation. The high number of different hydroxy sterols and bile ac...

Glycoursodeoxycholic Acid