JA2131
Modify Date: 2024-01-06 17:38:06
JA2131 structure
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Common Name | JA2131 | ||
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| CAS Number | 6505-99-3 | Molecular Weight | 341.45200 | |
| Density | 1.48g/cm3 | Boiling Point | 562.5ºC at 760 mmHg | |
| Molecular Formula | C13H19N5O2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 294ºC | |
Use of JA2131JA2131 is a small molecular inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG) (IC50=0.4 μM). JA2131 regulate DNA damage responses, causes replication fork stalling and cancer cell death[1][2]. |
| Name | 1,3-dimethyl-8-(2-morpholin-4-ylethylsulfanyl)-6-sulfanylidene-7H-purin-2-one |
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| Description | JA2131 is a small molecular inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG) (IC50=0.4 μM). JA2131 regulate DNA damage responses, causes replication fork stalling and cancer cell death[1][2]. |
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| Related Catalog | |
| In Vitro | JA2131 (10 mM; 1-2 h) 诱导 PC3 细胞 PARP1 过度磷酸化[1]。 Ja2131 (10 μM; 2 周) 抑制 MCF-7、PC3 和 MDA-MB-231 细胞集落形成，(0.1 μM-1 mM; 72 h) 对 MRC-50 细胞有抑制作用，IC50 为 132 μM[1]。 Ja2131 (5 μM; 72 h) 抑制 PC3 和 A172 胶质母细胞瘤细胞活力[1]。 Ja2131 (10 μM; 2 h) 可能作用于 HeLa 细胞的复制叉[1]。 Cell Viability Assay[1] Cell Line: PC3, and A172 glioblastoma cells Concentration: 0.1 μM-10 mM Incubation Time: 72 hours Result: Inhibited cell viability with IC50s of 33.05 μM (PC3 cells) and 55.34 μM (A172 cells), respectively. |
| References |
| Density | 1.48g/cm3 |
|---|---|
| Boiling Point | 562.5ºC at 760 mmHg |
| Molecular Formula | C13H19N5O2S2 |
| Molecular Weight | 341.45200 |
| Flash Point | 294ºC |
| Exact Mass | 341.09800 |
| PSA | 125.47000 |
| LogP | 0.69180 |
| Index of Refraction | 1.704 |
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JA2131 CAS#:6505-99-3 |
| Literature: Dietz,A.J.; Burgison,R.M. Journal of Medicinal Chemistry, 1966 , vol. 9, p. 500 - 506 |
| Precursor 2 | |
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| DownStream 0 | |