iKIX1
Modify Date: 2023-01-11 17:06:33
iKIX1 structure
|
Common Name | iKIX1 | ||
|---|---|---|---|---|
| CAS Number | 656222-54-7 | Molecular Weight | 303.168 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H8Cl2N4OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of iKIX1A small-molecule inhibitor of the interaction of the C. glabrata Pdr1 activation domain with the C. glabrata Gal11A KIX domain with Ki of 18 uM; blocks Gal11/Med15 recruitment and inhibits Pdr1-dependent gene activation and re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in animal models for disseminated and urinary tract C. glabrata infection; a novel therapeutic strategy in fungal infectious disease. |
| Name | iKIX1 |
|---|---|
| Synonym | More Synonyms |
| Description | A small-molecule inhibitor of the interaction of the C. glabrata Pdr1 activation domain with the C. glabrata Gal11A KIX domain with Ki of 18 uM; blocks Gal11/Med15 recruitment and inhibits Pdr1-dependent gene activation and re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in animal models for disseminated and urinary tract C. glabrata infection; a novel therapeutic strategy in fungal infectious disease. |
|---|---|
| References | References 1. Nishikawa JL, et al. Nature. 2016 Feb 25;530(7591):485-9. View Related Products by Target Fungal |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C10H8Cl2N4OS |
| Molecular Weight | 303.168 |
| Exact Mass | 301.979584 |
| LogP | 2.26 |
| Index of Refraction | 1.681 |
| 2-(Cyanoacetyl)-N-(3,4-dichlorophenyl)hydrazinecarbothioamide |
| 3-[(2-Cyanoacetyl)amino]-1-(3,4-dichlorophenyl)thiourea |
| MFCD00119122 |
| iKIX1 |
| 2-(2-cyanoacetyl)-N-(3,4-dichlorophenyl)hydrazine-1-carbothioamide |
| Acetic acid, 2-cyano-, 2-[[(3,4-dichlorophenyl)amino]thioxomethyl]hydrazide |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: iKIX1
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: iKIX1
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: iKIX1
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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