METHYL 3-(5-BROMOPYRIDIN-2-YL)-2-(TERT-BUTOXYCARBONYL)PROPANOATE

Modify Date: 2024-04-05 16:45:51

METHYL 3-(5-BROMOPYRIDIN-2-YL)-2-(TERT-BUTOXYCARBONYL)PROPANOATE Structure
METHYL 3-(5-BROMOPYRIDIN-2-YL)-2-(TERT-BUTOXYCARBONYL)PROPANOATE structure
Common Name METHYL 3-(5-BROMOPYRIDIN-2-YL)-2-(TERT-BUTOXYCARBONYL)PROPANOATE
CAS Number 656801-27-3 Molecular Weight 344.201
Density 1.4±0.1 g/cm3 Boiling Point 376.8±37.0 °C at 760 mmHg
Molecular Formula C14H18BrNO4 Melting Point N/A
MSDS N/A Flash Point 181.7±26.5 °C

 Names

Name 3-O-tert-butyl 1-O-methyl 2-[(5-bromopyridin-2-yl)methyl]propanedioate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 376.8±37.0 °C at 760 mmHg
Molecular Formula C14H18BrNO4
Molecular Weight 344.201
Flash Point 181.7±26.5 °C
Exact Mass 343.041901
PSA 65.49000
LogP 2.46
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.521

 Synthetic Route

~54%

METHYL 3-(5-BROMOPYRIDIN-2-YL)-2-(TERT-BUTOXYCARBONYL)PROPANOATE Structure

METHYL 3-(5-BRO...

CAS#:656801-27-3

Literature: ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2007/60409 A1, 2007 ; Location in patent: Page/Page column 86 ; WO 2007/060409 A1

~74%

METHYL 3-(5-BROMOPYRIDIN-2-YL)-2-(TERT-BUTOXYCARBONYL)PROPANOATE Structure

METHYL 3-(5-BRO...

CAS#:656801-27-3

Literature: Wang, Limin; Qu, Wenchao; Lieberman, Brian; Ploessl, Karl; Kung, Hank F. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3482 - 3485

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

Methyl 2-methyl-2-propanyl [(5-bromo-2-pyridinyl)methyl]malonate
Propanedioic acid, 2-[(5-bromo-2-pyridinyl)methyl]-, 1,1-dimethylethyl methyl ester