Etamicastat hydrochloride
Modify Date: 2024-01-16 15:20:26
Etamicastat hydrochloride structure
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Common Name | Etamicastat hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 677773-32-9 | Molecular Weight | 347.81100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H16ClF2N3OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Etamicastat hydrochlorideEtamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM[1]. Etamicastat can be used in the research of cardiovascular diseases[2]. |
| Name | Etamicastat hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM[1]. Etamicastat can be used in the research of cardiovascular diseases[2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 107 nM (DBH)[1] |
| In Vitro | Etamicastat blocks the hERG current amplitude with an IC50 value of 44 μg/mL (141 μM)[2]. |
| In Vivo | Etamicastat (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels[1]. Etamicastat (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats[1]. Animal Model: NMRi mice[1] Dosage: 100 mg/kg Administration: Administered intraperitoneally Result: Led to a significant reduction of noradrenaline levels (36% control) in heart with concomitant increasing in dopamine levels (850% of control). Animal Model: Male Wistar rats[1] Dosage: 50 mg/kg (Pharmacokinetic Analysis) Administration: Orally administered with at a dose volume of 10 mL/kg Result: Oral bioavailability (64%), Cmax (4.9 nM), and (T1/2=3.7 h). |
| References |
| Molecular Formula | C14H16ClF2N3OS |
|---|---|
| Molecular Weight | 347.81100 |
| Exact Mass | 347.06700 |
| PSA | 88.06000 |
| LogP | 4.00360 |
| Precursor 0 | |
|---|---|
| DownStream 1 | |
CAS#:760173-05-5| (R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydro-2H-imidazole-2-thione hydrochloride |
| (R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione hydrochloride |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Etamicastat hydrochloride
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
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