[DGlp1,DPhe2,DTrp3,6]-LH-RH

Modify Date: 2024-01-10 08:52:03

[DGlp1,DPhe2,DTrp3,6]-LH-RH structure	Common Name	[DGlp1,DPhe2,DTrp3,6]-LH-RH
	CAS Number	68059-94-9	Molecular Weight	1321.48000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₇H₈₄N₁₆O₁₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS08	Signal Word	Danger

Use of [DGlp1,DPhe2,DTrp3,6]-LH-RH

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist[1].

Name	[DGlp1,DPhe2,DTrp3,6]-LH-RH
Synonym	More Synonyms

Description	[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GNRH Receptor Research Areas >> Endocrinology
Target	GnRH receptor[1]
In Vitro	[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH (1 μM), together with LH-RH and FSH, blocks the inhibition of FSH-induced steroidogenesis in rat ovary granulosa cells[3].
In Vivo	[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH (1.25 and 2.5 mg, subcutaneous injection, b.i.d, for 7 days) prolongs pregnancy in rats[1]. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH (250 μg) inhibits ovulation by 100% in rats[2].

Molecular Formula	C₆₇H₈₄N₁₆O₁₃
Molecular Weight	1321.48000
Exact Mass	1320.64000
PSA	459.24000
LogP	4.47690

[DGlp1,DPhe2,DTrp3,6]-LH-RH MSDS(Chinese)

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R60
Safety Phrases	53-22-36/37/39-45
RIDADR	NONH for all modes of transport

Characterization of Leydig cell gonadotropin-releasing hormone binding sites utilizing radiolabeled agonist and antagonist.

Peptides 3(5) , 789-92, (1982)

Gonadotropin-releasing hormone (GnRH) binding sites in intact Leydig cells and in membrane preparations were investigated using 125I-labeled GnRH agonist and antagonist. Binding was saturable and invo...

Role of lipids in gonadotropin releasing hormone agonists and antagonist binding to rat pituitary.

Biochem. Biophys. Res. Commun. 105(1) , 8-13, (1982)

Digestion of pituitary membranes with phospholipase A 2 and phospholipase C abolished, in a dose responsive manner, the specific binding of gonadotropin releasing hormone agonist and antagonist. These...

LH-RH analogue acts as substance P antagonist by inhibiting spinal cord vasomotor responses.

Brain Res. 337(2) , 357-61, (1985)

Intrathecal injections of the luteinizing hormone-releasing hormone (LH-RH) analogue, [D-pGlu1-D-Phe2-D-Trp3,6]-LH-RH caused dose-dependent decreases in mean arterial blood pressure in anesthetized ra...

D-pglu1,D-phe2,D-trp3,6-luteinizing*hormone relea

pglu(1)-phe(2)-trp(3,6)-lhr

LHRH,pGlu(1)-Phe(2)-Trp(3,6)

[D-PGLU1,D-PHE2,D-TRP3,6]-LH-RH

[D-PYR1,D-PHE2,D-TRP3,6]-LH-RH (HUMAN)

(D-PYR1,D-PHE2,D-TRP3,6)-LHRH

DGLP-DPHE-DTRP-SER-TYR-DTRP-LEU-ARG-PRO-GLY-NH2

[D-PYROGLU1,D-PHE2,D-TRP3,6]-LH-RH

(D-Pyr1,D-Phe2,D-Trp3

GL Biochem (Shanghai) Ltd.
China
Product Name: [DGlp1,DPhe2,DTrp3,6]-LH-RH
Price: $Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Use of [DGlp1,DPhe2,DTrp3,6]-LH-RH

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[DGlp1,DPhe2,DTrp3,6]-LH-RH Biological Activity

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