Quazinone (Ro 13-6438)
Quazinone (Ro 13-6438) structure
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Common Name | Quazinone (Ro 13-6438) | ||
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| CAS Number | 70018-51-8 | Molecular Weight | 235.67000 | |
| Density | 1.57g/cm3 | Boiling Point | 345.6ºC at 760 mmHg | |
| Molecular Formula | C11H10ClN3O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 162.8ºC | |
Use of Quazinone (Ro 13-6438)Quazinone, is a phosphodiesterase 3 (PDE3) inhibitor and novel cardiotonic agent with vasodilating properties. |
| Name | quazinone |
|---|---|
| Synonym | More Synonyms |
| Density | 1.57g/cm3 |
|---|---|
| Boiling Point | 345.6ºC at 760 mmHg |
| Molecular Formula | C11H10ClN3O |
| Molecular Weight | 235.67000 |
| Flash Point | 162.8ºC |
| Exact Mass | 235.05100 |
| PSA | 44.70000 |
| LogP | 1.36370 |
| Index of Refraction | 1.746 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model.
J. Biomol. Screen. 11(5) , 457-68, (2006) The squamous cell carcinoma HeLa cell line and an epithelial cell line hTERT-RPE with a nonmalignant phenotype were interrogated for HeLa cell selectivity in response to 1267 annotated compounds repre... |
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Role of cGMP-inhibited phosphodiesterase and sarcoplasmic calcium in mediating the increase in basal heart rate with nitric oxide donors.
J. Mol. Cell. Cardiol. 32(10) , 1831-40, (2000) Nitric oxide (NO) donors increase heart rate (HR) through a guanylyl cyclase-dependent stimulation of the pacemaker current I(f), without affecting basal I(Ca-L). The activity of I(f)is known to be en... |
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Relaxation of human ureteral smooth muscle in vitro by modulation of cyclic nucleotide-dependent pathways.
Urol. Res. 28(2) , 110-5, (2000) Phosphodiesterases (PDE) are key enzymes regulating intracellular cyclic nucleotide turnover and, thus, smooth muscle tension. Recent reports have indicated the presence of PDE isoenzymes 1, 2, 4, and... |
| MFCD00211176 |