Itazigrel

Modify Date: 2024-01-03 11:34:40

Itazigrel Structure
Itazigrel structure
Common Name Itazigrel
CAS Number 70529-35-0 Molecular Weight 365.36900
Density 1.285g/cm3 Boiling Point 400.3ºC at 760 mmHg
Molecular Formula C18H14F3NO2S Melting Point N/A
MSDS N/A Flash Point 195.9ºC

 Names

Name 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)-1,3-thiazole
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.285g/cm3
Boiling Point 400.3ºC at 760 mmHg
Molecular Formula C18H14F3NO2S
Molecular Weight 365.36900
Flash Point 195.9ºC
Exact Mass 365.07000
PSA 59.59000
LogP 5.51310
Index of Refraction 1.547

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ2983000
CHEMICAL NAME :
Thiazole, 4,5-bis(4-methoxyphenyl)-2-trifluoromethyl-
CAS REGISTRY NUMBER :
70529-35-0
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H14-F3-N-O2-S
MOLECULAR WEIGHT :
365.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4659726
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THHADQ Thrombosis and Haemostasis. (F.K. Schattauer Verlag, Postfach 104545, D-70040 Stuttgart, Germany) V.35- 1976- Volume(issue)/page/year: 46,26,1981

 Synthetic Route

~%

Itazigrel Structure

Itazigrel

CAS#:70529-35-0

Literature: Rynbrandt, Ronald H.; Nishizawa, Edward E.; Balogoyen, Doris P.; Mendoza, A. Rene; Annis, Kathleen A. Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1507 - 1510

~34%

Itazigrel Structure

Itazigrel

CAS#:70529-35-0

Literature: Rynbrandt, R. H.; Nishizawa, E.- E.; Balogoyen, D. P.; Mendoza, A. R.; Annis, U. A. J. Med. Chem., 1981 , vol. 24, p. 1507 - 1510 View citing articles Show Details Gmelin Handbook: F: PerFHalOrg.SVol.1, 6.2.1.2, page 193 - 198 Show Details The Upjohn Co., Rynbrandt, R. H. Patent: DE2836742 , 1979 ; C.A., 1979 , vol. 91, p. 20490

 Synonyms

4,5-bis(p-Methoxyphenyl)-2-(trifluoromethyl)thiazole
2-Trifluormethyl-4,5-bis(p-methoxyphenyl)thiazole
Itazigrelum [Latin]
Itazogrel
ITAZIGREL
4,5-bis-(4-methoxy-phenyl)-2-trifluoromethyl-thiazole
2-Trifluormethyl-4,5-di-p-anisylthiazol