Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl-

Modify Date: 2024-01-10 14:57:47

Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl- Structure
Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl- structure
Common Name Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl-
CAS Number 71171-94-3 Molecular Weight 193.21700
Density 1.13g/cm3 Boiling Point 258ºC at 760 mmHg
Molecular Formula C11H12FNO Melting Point N/A
MSDS N/A Flash Point N/A

 Names

Name 2-(4-fluorophenyl)-4,4-dimethyl-5H-1,3-oxazole

 Chemical & Physical Properties

Density 1.13g/cm3
Boiling Point 258ºC at 760 mmHg
Molecular Formula C11H12FNO
Molecular Weight 193.21700
Exact Mass 193.09000
PSA 21.59000
LogP 1.81670
Index of Refraction 1.529

 Synthetic Route

~94%

Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl- Structure

Oxazole, 2-(4-f...

CAS#:71171-94-3

Literature: ASTRAZENECA AB Patent: US2008/15237 A1, 2008 ; Location in patent: Page/Page column 33 ; US 20080015237 A1

~71%

Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl- Structure

Oxazole, 2-(4-f...

CAS#:71171-94-3

Literature: Ackermann, Lutz; Barfuesser, Sebastian; Kornhaass, Christoph; Kapdi, Anant R. Organic Letters, 2011 , vol. 13, # 12 p. 3082 - 3085

~%

Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl- Structure

Oxazole, 2-(4-f...

CAS#:71171-94-3

Literature: Pfizer Inc. Patent: US6051601 A1, 2000 ; US 6051601 A

~%

Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl- Structure

Oxazole, 2-(4-f...

CAS#:71171-94-3

Literature: Dondoni, Alessandro; Fogagnolo, Marco; Fantin, Giancarlo; Medici, Alessandro; Pedrini, Paola Tetrahedron Letters, 1986 , vol. 27, # 43 p. 5269 - 5270

~%

Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl- Structure

Oxazole, 2-(4-f...

CAS#:71171-94-3

Literature: Dondoni, Alessandro; Fogagnolo, Marco; Fantin, Giancarlo; Medici, Alessandro; Pedrini, Paola Tetrahedron Letters, 1986 , vol. 27, # 43 p. 5269 - 5270

~%

Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl- Structure

Oxazole, 2-(4-f...

CAS#:71171-94-3

Literature: Newman,M.S.; Kannan,R. Journal of Organic Chemistry, 1979 , vol. 44, p. 3388 - 3390

~%

Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl- Structure

Oxazole, 2-(4-f...

CAS#:71171-94-3

Literature: Schull, Terence L.; Brandow, Susan L.; Dressick, Walter J. Tetrahedron Letters, 2001 , vol. 42, # 32 p. 5373 - 5376

~%

Oxazole, 2-(4-fluorophenyl)-4,5-dihydro-4,4-dimethyl- Structure

Oxazole, 2-(4-f...

CAS#:71171-94-3

Literature: Yamaguchi; Koga; Kamei; Akima; Maruyama; Kuroki; Hamana; Ohi Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 9 p. 1850 - 1853