COH-SR4
Modify Date: 2024-09-27 10:49:49
COH-SR4 structure
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Common Name | COH-SR4 | ||
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| CAS Number | 73439-19-7 | Molecular Weight | 350.027 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 363.2±42.0 °C at 760 mmHg | |
| Molecular Formula | C13H8Cl4N2O | Melting Point | 298-300 °C | |
| MSDS | N/A | Flash Point | 173.5±27.9 °C | |
Use of COH-SR4COH-SR4 (Mitochondria uncoupler SR4) is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling; prevents cell proliferation and promoted cell death in many human cancers including leukemia, lung cancer, melanoma, and hepatocarcinoma in vitro and in animal models; exhibits a strong inhibitory effect on the survival of melanoma cells (B16-F0 cell line IC50=5 uM, Hs600T cell lineI C50=6 uM, and A2058 cell line IC50=11 uM), does not cause any significant cytotoxicity in normal human aortic vascular smooth muscle cells (HAVSMC); inhibits vemurafenib-resistant melanoma in vivo. |
| Name | 1,3-Bis(3,5-dichlorophenyl)urea |
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| Synonym | More Synonyms |
| Description | COH-SR4 (Mitochondria uncoupler SR4) is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling; prevents cell proliferation and promoted cell death in many human cancers including leukemia, lung cancer, melanoma, and hepatocarcinoma in vitro and in animal models; exhibits a strong inhibitory effect on the survival of melanoma cells (B16-F0 cell line IC50=5 uM, Hs600T cell lineI C50=6 uM, and A2058 cell line IC50=11 uM), does not cause any significant cytotoxicity in normal human aortic vascular smooth muscle cells (HAVSMC); inhibits vemurafenib-resistant melanoma in vivo. |
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| References | References 1. Singhal SS, et al. Biochem Pharmacol. 2012 Dec 1;84(11):1419-27. 2. Figarola JL, et al. Oncotarget. 2018 Dec 11;9(97):36945-36965. 3. Singhal SS, et al. Biochem Pharmacol. 2013 Dec 15;86(12):1664-72. 4. Figarola JL, et al. PLoS One. 2013 Dec 20;8(12):e83801. View Related Products by Target Other Targets |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 363.2±42.0 °C at 760 mmHg |
| Melting Point | 298-300 °C |
| Molecular Formula | C13H8Cl4N2O |
| Molecular Weight | 350.027 |
| Flash Point | 173.5±27.9 °C |
| Exact Mass | 347.939087 |
| LogP | 7.01 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.706 |
| Hazard Codes | Xn |
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| Urea, N,N'-bis(3,5-dichlorophenyl)- |
| 1,3-Bis(3,5-dichlorophenyl)urea |
| MFCD01566238 |