Chlorotrimethylsilane

Modify Date: 2024-01-02 14:15:05

Chlorotrimethylsilane structure	Common Name	Chlorotrimethylsilane
	CAS Number	75-77-4	Molecular Weight	108.642
	Density	0.9±0.1 g/cm3	Boiling Point	58.7±9.0 °C at 760 mmHg
	Molecular Formula	C₃H₉ClSi	Melting Point	−40 °C(lit.)
	MSDS	Chinese USA	Flash Point	-27.8±0.0 °C
	Symbol	GHS02, GHS05, GHS06	Signal Word	Danger

Name	chlorotrimethylsilane
Synonym	More Synonyms

Density	0.9±0.1 g/cm3
Boiling Point	58.7±9.0 °C at 760 mmHg
Melting Point	−40 °C(lit.)
Molecular Formula	C₃H₉ClSi
Molecular Weight	108.642
Flash Point	-27.8±0.0 °C
Exact Mass	108.016205
LogP	2.17
Vapour density	3.7 (vs air)
Vapour Pressure	219.8±0.1 mmHg at 25°C
Index of Refraction	1.388
Stability	Stable. Highly flammable - note low flash point. Reacts violently with water. Incompatible with water, moisture, strong oxidizing agents, strong acids, strong bases, aldehydes, alcohols, amines, esters, ketones.
Water Solubility	REACTS

Chlorotrimethylsilane MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VV2710000

CHEMICAL NAME :: Silane, chlorotrimethyl-

CAS REGISTRY NUMBER :: 75-77-4

BEILSTEIN REFERENCE NO. :: 1209232

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C3-H9-Cl-Si

MOLECULAR WEIGHT :: 108.66

WISWESSER LINE NOTATION :: G-SI-1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5660 uL/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - other changes

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Immunological Including Allergic - decreased immune response

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1780 uL/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg/I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 mg/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl 7),1,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83272 No. of Facilities: 59 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 200 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83272 No. of Facilities: 8 (estimated) No. of Industries: 2 No. of Occupations: 15 No. of Employees: 1876 (estimated) No. of Female Employees: 20 (estimated)

Symbol	GHS02, GHS05, GHS06
Signal Word	Danger
Hazard Statements	H225-H301 + H331-H312-H314
Supplemental HS	Corrosive to the respiratory tract., Reacts violently with water.
Precautionary Statements	P210-P261-P280-P301 + P310-P305 + P351 + P338-P310
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US)
Hazard Codes	C:Corrosive
Risk Phrases	R11;R14;R21;R34
Safety Phrases	S26-S36/37/39-S45-S16-S36/37
RIDADR	UN 2924 3/PG 2
WGK Germany	2
RTECS	VV2710000
Packaging Group	II
Hazard Class	3
HS Code	29310095

Precursor 10
CAS#:1825-62-3 Ethoxy(trimethy... CAS#:1825-61-2 Trimethyl Metho... CAS#:18306-29-1 Bis(trimethylsi... CAS#:993-07-7 trimethylsilane
CAS#:75-76-3 TMS CAS#:107-46-0 Hexamethyldisiloxane CAS#:999-97-3 Hexamethyldisilazane CAS#:33861-17-5 trimethyl(pheny...
CAS#:2083-91-2 N-(Trimethylsil... CAS#:75-79-6 Methyltrichloro...
DownStream 10
CAS#:10557-63-8 N-phenyl-N-trim... CAS#:72535-69-4 N-Phenylethanim... CAS#:111043-32-4 N-benzyl-3-chlo... CAS#:108164-62-1 trimethyl(1-phe...
CAS#:108164-63-2 trimethyl((1-ph... CAS#:109801-20-9 2,2,6,6-tetrame... CAS#:108536-14-7 1,2-Dioxetane, ... CAS#:100693-33-2 [cyclohexen-1-y...
CAS#:107940-11-4 (Z)-4-methoxy-2... CAS#:107940-12-5 (1-methoxy-2-tr...

HS Code	29310095

ALD1 Regulates Basal Immune Components and Early Inducible Defense Responses in Arabidopsis.

Mol. Plant Microbe Interact. 28(4) , 455-66, (2015)

Robust immunity requires basal defense machinery to mediate timely responses and feedback cycles to amplify defenses against potentially spreading infections. AGD2-LIKE DEFENSE RESPONSE PROTEIN 1 (ALD...

Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1).

PLoS ONE 10 , e0141252, (2015)

Cytochrome P450c17 (P450 17A1, CYP17A1) is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer. Cytochrome P450c17 can exhibit either one or...

Overcoming the equivalent-chain-length rule with pH-zone-refining countercurrent chromatography for the preparative separation of fatty acids.

Anal. Bioanal. Chem 407 , 5503-11, (2015)

Purification of individual fatty acids from vegetable oils by preparative liquid chromatography techniques such as countercurrent chromatography (CCC) is a challenging task due to the equivalent-chain...

Chlorotrimethylsilane

MFCD00000502

EINECS 200-900-5

chloro(trimethyl)silane