Antitrypanosomal agent 1
Modify Date: 2024-01-13 17:48:20
Antitrypanosomal agent 1 structure
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Common Name | Antitrypanosomal agent 1 | ||
|---|---|---|---|---|
| CAS Number | 75144-12-6 | Molecular Weight | 282.59400 | |
| Density | 1.22g/cm3 | Boiling Point | 341.9ºC at 760 mmHg | |
| Molecular Formula | C11H14Cl3NO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 160.6ºC | |
Use of Antitrypanosomal agent 1Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity[1]. |
| Name | 1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity[1]. |
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| Related Catalog | |
| Target |
IC50: 3.3 μM (trypanothione reductase) and 64.8 μM (glutathione reductase)[1] EC50: 1 μM (T. brucei)[1] |
| In Vitro | Antitrypanosomal agent 1 (compound 8a) has an selectivity for TR (GR IC50/TR IC50) of 20[1]. |
| References |
| Density | 1.22g/cm3 |
|---|---|
| Boiling Point | 341.9ºC at 760 mmHg |
| Molecular Formula | C11H14Cl3NO |
| Molecular Weight | 282.59400 |
| Flash Point | 160.6ºC |
| Exact Mass | 281.01400 |
| PSA | 20.31000 |
| LogP | 3.92980 |
| Index of Refraction | 1.544 |
| Storage condition | 2-8℃ |
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~84%
Antitrypanosoma... CAS#:75144-12-6 |
| Literature: Shanghai Institute of Pharmaceutical Industry; Li, Jianqi; Zheng, Yongyong; Liao, Yunfeng; Li, Yali Patent: US2013/72488 A1, 2013 ; Location in patent: Paragraph 0165 ; |
|
~49%
Antitrypanosoma... CAS#:75144-12-6 |
| Literature: Du, Xiaohui; Guo, Chun; Hansell, Elizabeth; Doyle, Patricia S.; Caffrey, Conor R.; Holler, Tod P.; McKerrow, James H.; Cohen, Fred E. Journal of Medicinal Chemistry, 2002 , vol. 45, # 13 p. 2695 - 2707 |
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~%
Antitrypanosoma... CAS#:75144-12-6 |
| Literature: Shanghai Institute of Pharmaceutical Industry; Li, Jianqi; Zheng, Yongyong; Liao, Yunfeng; Li, Yali Patent: US2013/72488 A1, 2013 ; |
CAS#:50516-63-7| 1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanone HCl |
| AmbscPOD_38/0850 |
| 1-(3,4-dichlorophenyl)-3-dimethylamino-1-propanone hydrochloride |