Bromocresol Green

Modify Date: 2024-01-02 17:34:13

Bromocresol Green Structure
Bromocresol Green structure
Common Name Bromocresol Green
CAS Number 76-60-8 Molecular Weight 698.01
Density 2.1±0.1 g/cm3 Boiling Point 626.0±55.0 °C at 760 mmHg
Molecular Formula C21H14Br4O5S Melting Point 225 °C
MSDS USA Flash Point 332.4±31.5 °C
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger

 Use of Bromocresol Green


Bromocresol green is a pH-sensitive triphenylmethane dye commonly used for the determination of protein and albumin in serum. Bromocresol green is a bio-based dye with a yellow-green to blue-green color. Bromocresol green turns yellow (λmax=435 nm, protonated form) when placed in acidic solution (e.g. pH=4.15), and turns blue in basic solution (λmax=615 nm, deprotonated form). Bromocresol green is widely used as a pH indicator in the field of biochemical analysis. In addition, Bromocresol green is also used to detect the concentration of molecules such as creatinine, and to judge the viability of cells[1][2][3][4].

 Names

Name Bromocresol green
Synonym More Synonyms

 Bromocresol Green Biological Activity

Description Bromocresol green is a pH-sensitive triphenylmethane dye commonly used for the determination of protein and albumin in serum. Bromocresol green is a bio-based dye with a yellow-green to blue-green color. Bromocresol green turns yellow (λmax=435 nm, protonated form) when placed in acidic solution (e.g. pH=4.15), and turns blue in basic solution (λmax=615 nm, deprotonated form). Bromocresol green is widely used as a pH indicator in the field of biochemical analysis. In addition, Bromocresol green is also used to detect the concentration of molecules such as creatinine, and to judge the viability of cells[1][2][3][4].
Related Catalog
References

[1]. Delanghe S, et al. Binding of bromocresol green and bromocresol purple to albumin in hemodialysis patients. Clin Chem Lab Med. 2018 Feb 23;56(3):436-440.  

[2]. Jurmanović S, et al. Organically modified silicate thin films doped with colourimetric pH indicators methyl red and bromocresol green as pH responsive sol–gel hybrid materials[J]. Thin Solid Films, 2010, 518(8): 2234-2240.

[3]. Chaiyo S, et al. A novel paper-based colorimetry device for the determination of the albumin to creatinine ratio. Analyst. 2018 Nov 5;143(22):5453-5460.  

[4]. Hou H, et al. Single-cell pH imaging and detection for pH profiling and label-free rapid identification of cancer-cells. Sci Rep. 2017 May 11;7(1):1759.  

 Chemical & Physical Properties

Density 2.1±0.1 g/cm3
Boiling Point 626.0±55.0 °C at 760 mmHg
Melting Point 225 °C
Molecular Formula C21H14Br4O5S
Molecular Weight 698.01
Flash Point 332.4±31.5 °C
Exact Mass 693.729492
PSA 92.21000
LogP 7.80
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.716
Storage condition Store at RT.
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility slightly soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SJ7456000
CHEMICAL NAME :
Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-3 -methyl-, S,S-dioxide
CAS REGISTRY NUMBER :
76-60-8
BEILSTEIN REFERENCE NO. :
0372527
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C21-H14-Br4-O5-S
MOLECULAR WEIGHT :
698.05

 Safety Information

Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger
Hazard Statements H225-H319-H336
Precautionary Statements P210-P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S7-S16-S24/25-S26-S37/39
RIDADR UN 1219 3/PG 2
WGK Germany 3
RTECS SJ7456000
Hazard Class 3.0
HS Code 2934991000

 Synthetic Route

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Bromocresol Green Structure

Bromocresol Green

CAS#:76-60-8

Literature: Acta Physica et Chemica, , vol. 4, p. 73

~%

Bromocresol Green Structure

Bromocresol Green

CAS#:76-60-8

Literature: Canadian Journal of Chemistry, , vol. 69, # 6 p. 937 - 944

 Customs

HS Code 2934991000
Summary 2934991000. sultones and sultams. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

bromcresol green spray
m-Cresol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-, S,S-dioxide (8CI)
Bromocresol Green p.a.
MYCOBACTERIUM BOVIS
BCG
Bromcresol Green
BROMOCRESOL GREEN,ACS
2,2'-dimethyl-3,3',5,5'-tetrabromophenolsulfophthalein
EINECS 200-972-8
3',3'',5',5''-Tetrabromo-m-cresolsulfonephthalein
vertdebromocresol
2,2'-dimethyl-3,3',5,5'-tetrabromophenolsulphonephthalein
3',3",5',5"-tetrabromo-m-cresolsulfonapthalein
Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2,6-dibromo-3-methyl-
a,a-Bis(3,5-dibromo-4-hydroxy-o-tolyl)-a-hydroxytoluenesulfonic Acid g-Sultone
3′,3′′,5′,5′′-Tetrabromo-m-cresolsulfonephthalein
BCG,Mycobacterium bovis
4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis[2,6-dibromo-3-methylphenol] S,S-Dioxide
BBOT
3,3',5,5'-Tetrabromo-m-cresolsulfonphthalein
BROMOCRESOL BLUE
MFCD00005874
4,4'-(1,1-Dioxido-3H-2,1-benzoxathiole-3,3-diyl)bis(2,6-dibromo-3-methylphenol)
Bromocresol Green
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