TCPOBOP
TCPOBOP structure
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Common Name | TCPOBOP | ||
|---|---|---|---|---|
| CAS Number | 76150-91-9 | Molecular Weight | 402.05900 | |
| Density | 1.518g/cm3 | Boiling Point | 444.8ºC at 760 mmHg | |
| Molecular Formula | C16H8Cl4N2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 222.8ºC | |
Use of TCPOBOPTCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2]. |
| Name | 3,5-dichloro-2-[4-(3,5-dichloropyridin-2-yl)oxyphenoxy]pyridine |
|---|---|
| Synonym | More Synonyms |
| Description | TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2]. |
|---|---|
| Related Catalog | |
| Target |
Bcl-2 |
| In Vivo | TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours[1]. Animal Model: METfl/fl: Tam-Cre+/+ mice with a targeted deletion for exon 16 with MET KO[1] Dosage: 3 mg/kg Administration: Oral; 1, 2, 5 days Result: Increased Liver weight to body weight. |
| References |
| Density | 1.518g/cm3 |
|---|---|
| Boiling Point | 444.8ºC at 760 mmHg |
| Molecular Formula | C16H8Cl4N2O2 |
| Molecular Weight | 402.05900 |
| Flash Point | 222.8ºC |
| Exact Mass | 399.93400 |
| PSA | 44.24000 |
| LogP | 6.67480 |
| Index of Refraction | 1.635 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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