2-Methyl-2-propanyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazi nyl)methyl]benzoyl}-1-piperazinecarboxylate

Modify Date: 2024-01-11 10:00:31

2-Methyl-2-propanyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazi nyl)methyl]benzoyl}-1-piperazinecarboxylate Structure
2-Methyl-2-propanyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazi nyl)methyl]benzoyl}-1-piperazinecarboxylate structure
Common Name 2-Methyl-2-propanyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazi nyl)methyl]benzoyl}-1-piperazinecarboxylate
CAS Number 763114-04-1 Molecular Weight 466.50500
Density N/A Boiling Point N/A
Molecular Formula C25H27FN4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Names

Name 2-Methyl-2-propanyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazi nyl)methyl]benzoyl}-1-piperazinecarboxylate
Synonym More Synonyms

 Chemical & Physical Properties

Molecular Formula C25H27FN4O4
Molecular Weight 466.50500
Exact Mass 466.20200
PSA 95.86000
LogP 3.63400

 Synthetic Route

~96%

2-Methyl-2-propanyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazi nyl)methyl]benzoyl}-1-piperazinecarboxylate Structure

2-Methyl-2-prop...

CAS#:763114-04-1

Literature: Menear, Keith A.; Adcock, Claire; Boulter, Robert; Cockcroft, Xiao-Ling; Copsey, Louise; Cranston, Aaron; Dillon, Krystyna J.; Drzewiecki, Jan; Garman, Sheila; Gomez, Sylvie; Javaid, Hashim; Kerrigan, Frank; Knights, Charlotte; Lau, Alan; Loh Jr., Vincent M.; Matthews, Ian T. W.; Moore, Stephen; O'Connor, Mark J.; Smith, Graeme C. M.; Martin, Niall M. B. Journal of Medicinal Chemistry, 2008 , vol. 51, # 20 p. 6581 - 6591

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2-Methyl-2-propanyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazi nyl)methyl]benzoyl}-1-piperazinecarboxylate Structure

2-Methyl-2-prop...

CAS#:763114-04-1

Literature: SHANGHAI DE NOVO PHARMATECH CO LTD.; GAO, Daxin Patent: WO2012/71684 A1, 2012 ; WO 2012/071684 A1

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2-Methyl-2-propanyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazi nyl)methyl]benzoyl}-1-piperazinecarboxylate Structure

2-Methyl-2-prop...

CAS#:763114-04-1

Literature: SHANGHAI DE NOVO PHARMATECH CO LTD.; GAO, Daxin Patent: WO2012/71684 A1, 2012 ; WO 2012/071684 A1

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2-Methyl-2-propanyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazi nyl)methyl]benzoyl}-1-piperazinecarboxylate Structure

2-Methyl-2-prop...

CAS#:763114-04-1

Literature: SHANGHAI DE NOVO PHARMATECH CO LTD.; GAO, Daxin Patent: WO2012/71684 A1, 2012 ; WO 2012/071684 A1

~%

2-Methyl-2-propanyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazi nyl)methyl]benzoyl}-1-piperazinecarboxylate Structure

2-Methyl-2-prop...

CAS#:763114-04-1

Literature: SHANGHAI DE NOVO PHARMATECH CO LTD.; GAO, Daxin Patent: WO2012/71684 A1, 2012 ; WO 2012/071684 A1

~%

2-Methyl-2-propanyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazi nyl)methyl]benzoyl}-1-piperazinecarboxylate Structure

2-Methyl-2-prop...

CAS#:763114-04-1

Literature: SHANGHAI DE NOVO PHARMATECH CO LTD.; GAO, Daxin Patent: WO2012/71684 A1, 2012 ; WO 2012/071684 A1

~%

2-Methyl-2-propanyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazi nyl)methyl]benzoyl}-1-piperazinecarboxylate Structure

2-Methyl-2-prop...

CAS#:763114-04-1

Literature: SHANGHAI DE NOVO PHARMATECH CO LTD.; Gao, Daxin Patent: US2013/224107 A1, 2013 ;

 Synonyms

tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-carboxylate
5-(4-tert-butoxycarbonyl-1-piperazinyl)benzofuran-2-carboxamide
4-[2-fluoro-5-(4-oxo-3,4-dihydro-phthalazin-1-ylmethyl)-benzoyl]-piperazine-1-carboxylic acid tert-butyl ester
tert-butyl 4-[2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]piperazine-1-carboxylate
Tert-butyl 4-(2-carbamoylbenzofuran-5-yl)piperazine-1-carboxylate
tert-butyl 4-[2-(aminocarbonyl)-1-benzofuran-5-yl]piperazine-1-carboxylate