Euphorbia factor L1

Modify Date: 2024-01-02 13:04:03

Euphorbia factor L1 Structure
Euphorbia factor L1 structure
 Common Name Euphorbia factor L1
CAS Number 76376-43-7 Molecular Weight 552.655
Density 1.2±0.1 g/cm3 Boiling Point 633.1±55.0 °C at 760 mmHg
Molecular Formula C32H40O8 Melting Point N/A
MSDS N/A Flash Point 263.9±31.5 °C

 Use of Euphorbia factor L1


Euphorbia Factor L1 is a diterpenoid from Euphorbia lathyris L., reduces the expression of Bcl-2, PI3K, AKT and mTOR protein and mRNA, upregulates cleaved caspase-9 and caspase-3 levels, buts shows no effect on pro-caspase-9 and pro-caspase-3. Euphorbia Factor L1 induces apoptosis, has anticancer, antiadipogenesis, antiosteoclastogenesis and multidrug resistance-modulating effect[1].

 Names

Name 5-Phosphononorvaline
Synonym More Synonyms

 Euphorbia factor L1 Biological Activity

Description Euphorbia Factor L1 is a diterpenoid from Euphorbia lathyris L., reduces the expression of Bcl-2, PI3K, AKT and mTOR protein and mRNA, upregulates cleaved caspase-9 and caspase-3 levels, buts shows no effect on pro-caspase-9 and pro-caspase-3. Euphorbia Factor L1 induces apoptosis, has anticancer, antiadipogenesis, antiosteoclastogenesis and multidrug resistance-modulating effect[1].
Related Catalog
References

[1]. Zhu A, et al. Effect of euphorbia factor L1 on oxidative stress, apoptosis, and autophagy in human gastric epithelial cells. Phytomedicine. 2019 Apr 16;64:152929.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 633.1±55.0 °C at 760 mmHg
Molecular Formula C32H40O8
Molecular Weight 552.655
Flash Point 263.9±31.5 °C
Exact Mass 552.272339
PSA 108.50000
LogP 5.55
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.566
Storage condition 2-8°C

 Synonyms

EUPATOROXIN,10-EPI
Euphorbia Factor L1
Benzeneacetic acid, (1aR,4aR,6S,7S,7aR,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
(1aR,2Z,4aR,6S,7S,7aR,8R,9S,11aS)-4a,8-Diacetoxy-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate
Benzeneacetic acid, (1aR,2Z,4aR,6S,7S,7aR,8R,9S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
(1aR,4aR,6S,7S,7aR,8S,9R,11aS)-4a,8-Diacetoxy-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate
10-epi-Eupatoroxin
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Related Compounds: More...
Deoxy euphorbia factor L1
247099-01-0
Euphorbia factor L3
218916-52-0
Euphorbia factor L7b
93550-95-9
Euphorbia factor L8
218916-53-1
Euphorbia factor L7a
93550-94-8
Euphorbia factor L2
218916-51-9
Euphorbia factor L9
129393-28-8
Euphorbia factor L22
1613700-09-6
Euphorbia factor L24
1613700-13-2
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