DMHAPC-Chol

Modify Date: 2024-02-14 17:11:08

DMHAPC-Chol Structure
DMHAPC-Chol structure
Common Name DMHAPC-Chol
CAS Number 794494-38-5 Molecular Weight 559.9
Density N/A Boiling Point N/A
Molecular Formula C35H63N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DMHAPC-Chol


DMHAPC-Chol is a cationic cholesterol. Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B16-F10 cells. DMHAPC-Chol, as part of a lipoplex with DOPE, has also been used to deliver DNA into mouse lung via intratracheal injection, resulting in a heterogeneous distribution in the bronchi and bronchioles, and to deliver VEGF siRNA into A431 and MDA-MB-231 cells, which secrete VEGF.

 Names

Name DMHAPC-Chol

 DMHAPC-Chol Biological Activity

Description DMHAPC-Chol is a cationic cholesterol. Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B16-F10 cells. DMHAPC-Chol, as part of a lipoplex with DOPE, has also been used to deliver DNA into mouse lung via intratracheal injection, resulting in a heterogeneous distribution in the bronchi and bronchioles, and to deliver VEGF siRNA into A431 and MDA-MB-231 cells, which secrete VEGF.

 Chemical & Physical Properties

Molecular Formula C35H63N2O3
Molecular Weight 559.9
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