Bulaquine
Modify Date: 2024-01-18 20:11:25
Bulaquine structure
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Common Name | Bulaquine | ||
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| CAS Number | 79781-00-3 | Molecular Weight | 369.45700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H27N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BulaquineBulaquine (CDRI 80/53) is a potent antimalarial agent which is an analogue of Primaquine (HY-12651A). Bulaquine affects multiple metabolism pathways and shows inhibition effect on Plasmodium cynomolgi infection. Bulaquine can be used for the research of malaria[1][2][3]. |
| Name | ablaquine |
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| Synonym | More Synonyms |
| Description | Bulaquine (CDRI 80/53) is a potent antimalarial agent which is an analogue of Primaquine (HY-12651A). Bulaquine affects multiple metabolism pathways and shows inhibition effect on Plasmodium cynomolgi infection. Bulaquine can be used for the research of malaria[1][2][3]. |
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| Related Catalog | |
| In Vivo | Bulaquine (40 mg/kg; p.o. once) affects multiple pathways in vivo[1]. Bulaquine (1.25 mg/kg; once daily; for 7 days) shows 100% curative anti-relapse activity with a primaquine index of 0.8 for rhesus monkeys with Plasmodium cynomolgi B infection[2]. Animal Model: 25-30 g male Swiss albino mice[1] Dosage: 40 mg/kg Administration: Oral gavage; 40 mg/kg once Result: Affected oxidative stress and fatty acid synthesis pathway, apoptosis, cell cycle, inflammatory response, glycogen metabolism, Kreb’s cycle, electron transport chain, fatty acid β-oxidation, MAPK signalling, signalling of hepatocyte growth factor receptor, matrix metalloproteinases, steroid biosynthesis, TGF-β signalling, translation factors, Wnt signalling, regulation of actin cytoskeleton, ribosomal proteins, RNA transcription reactome, proteasome degradation and nuclear receptors in lipid metabolism according to GO results. |
| Molecular Formula | C21H27N3O3 |
|---|---|
| Molecular Weight | 369.45700 |
| Exact Mass | 369.20500 |
| PSA | 72.48000 |
| LogP | 4.09840 |
| N1-(3-Acetyl-4,5-dihydrofuran-2-yl)-N4-(6-methoxyquinolin-8-yl)pentane-1,4-diamine |