Methoxypolyethylene glycol amine

Modify Date: 2024-01-05 12:24:32

Methoxypolyethylene glycol amine structure	Common Name	Methoxypolyethylene glycol amine
	CAS Number	80506-64-5	Molecular Weight	3400(Average)
	Density	1.1±0.1 g/cm3	Boiling Point	583.6±45.0 °C at 760 mmHg
	Molecular Formula	(C₂H₄O)nC₃H₉NO	Melting Point	58-61 °C(lit.)
	MSDS	USA	Flash Point	291.3±22.4 °C

Use of Methoxypolyethylene glycol amine

mPEG-amine (MW 3400) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

Name	Methoxypolyethylene glycol amine
Synonym	More Synonyms

Description	mPEG-amine (MW 3400) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).
Related Catalog	Research Areas >> Cancer
References	[1]. Han X, et al. 9-NC-loaded folate-conjugated polymer micelles as tumor targeted drug delivery system: preparation and evaluation in vitro. Int J Pharm. 2009 May 8;372(1-2):125-31.

Density	1.1±0.1 g/cm3
Boiling Point	583.6±45.0 °C at 760 mmHg
Melting Point	58-61 °C(lit.)
Molecular Formula	(C₂H₄O)nC₃H₉NO
Molecular Weight	3400(Average)
Flash Point	291.3±22.4 °C
Exact Mass	559.357
LogP	-4.59
Appearance of Characters	Granular Solid
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.458
Storage condition	−20°C
Water Solubility	Soluble in water

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	C
Safety Phrases	S22;S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3

Preparation of micelle-forming polymer-drug conjugates.

Bioconjug. Chem. 3 , 295, (1992)

Adriamycin, a hydrophobic anticancer drug, was conjugated with poly(ethylene oxide)-poly(aspartic acid) block copolymers composed of various lengths of each block copolymer segment ranging from 1000 t...

MFCD00131599

Methoxypoly(ethylene glycol) aMine

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