GADOPENTETIC ACID

Modify Date: 2024-01-02 20:10:27

GADOPENTETIC ACID Structure
GADOPENTETIC ACID structure
Common Name GADOPENTETIC ACID
CAS Number 80529-93-7 Molecular Weight 547.57300
Density N/A Boiling Point 721.1ºC at 760 mmHg
Molecular Formula C14H20GdN3O10 Melting Point 129ºC (dec.)(lit.)
MSDS N/A Flash Point 389.9ºC

 Use of GADOPENTETIC ACID


Gadopentetic acid (Gd-DTPA) is an paramagnetic contrast agent commonly implemented by a bolus intravenous injection (i.v.) in Dynamic contrast-enhanced MRI (DCE-MRI) studies. The initial concentration of Gadopentetic acid (Gd-DTPA) in the plasma ([Gd-DTPA0]) is an important parameter for DCE-MRI. [Gd-DTPA0] is related to the administered bolus dose and varies with subjects. A bolus of 0.025 mmol/kg Gd-DTPA offers shorter acquisition time and less exposure of subjects, with a half-life of 37.3 mins, a mean residence time of 53.8 mins, and an AUC of 3.37 ± 0.47 mmol/min/L[1].

 Names

Name gadopentetic acid
Synonym More Synonyms

 GADOPENTETIC ACID Biological Activity

Description Gadopentetic acid (Gd-DTPA) is an paramagnetic contrast agent commonly implemented by a bolus intravenous injection (i.v.) in Dynamic contrast-enhanced MRI (DCE-MRI) studies. The initial concentration of Gadopentetic acid (Gd-DTPA) in the plasma ([Gd-DTPA0]) is an important parameter for DCE-MRI. [Gd-DTPA0] is related to the administered bolus dose and varies with subjects. A bolus of 0.025 mmol/kg Gd-DTPA offers shorter acquisition time and less exposure of subjects, with a half-life of 37.3 mins, a mean residence time of 53.8 mins, and an AUC of 3.37 ± 0.47 mmol/min/L[1].
Related Catalog
References

[1]. Wan C, et al. Gd-DTPA-induced dynamic metabonomic changes in rat biofluids. Magn Reson Imaging. 2017 Dec;44:15-25.

[2]. Taheri S, et al. Analysis of pharmacokinetics of Gd-DTPA for dynamic contrast-enhanced magnetic resonance imaging. Magn Reson Imaging. 2016 Sep;34(7):1034-40.

 Chemical & Physical Properties

Boiling Point 721.1ºC at 760 mmHg
Melting Point 129ºC (dec.)(lit.)
Molecular Formula C14H20GdN3O10
Molecular Weight 547.57300
Flash Point 389.9ºC
Exact Mass 548.03900
PSA 204.71000

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-37/39
WGK Germany 3

 Synonyms

gadolinium diethylenetriaminepentaacetic acid
Acido gadopentetico
GADOPENTETATE
Gd acid spray
Acide gadopentetique
Acidum gadopenteticum
Gd(diethylenetriaminepentaacetic acid(-3H))
gadolinium 1,1,4,7,7-diethylenetriaminepentaacetate
gadoliniumdtpa
Gd-DTPA
Gadopentetic
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