COUMACHLOR

Modify Date: 2024-01-02 07:14:32

COUMACHLOR Structure
COUMACHLOR structure
Common Name COUMACHLOR
CAS Number 81-82-3 Molecular Weight 342.773
Density 1.4±0.1 g/cm3 Boiling Point 543.1±50.0 °C at 760 mmHg
Molecular Formula C19H15ClO4 Melting Point 168-170 °C(lit.)
MSDS Chinese USA Flash Point 282.3±30.1 °C
Symbol GHS08
GHS08
Signal Word Warning

 Use of COUMACHLOR


Coumachlor is a first genereation anticoagulant rodenticide which blocks formation of prothrombin and inhibits blood coagulation causing death by internal haemorrhage.

 Names

Name coumachlor
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 543.1±50.0 °C at 760 mmHg
Melting Point 168-170 °C(lit.)
Molecular Formula C19H15ClO4
Molecular Weight 342.773
Flash Point 282.3±30.1 °C
Exact Mass 342.065887
PSA 67.51000
LogP 4.01
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.641

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GN4830000
CHEMICAL NAME :
Coumarin, 3-(alpha-acetonyl-p-chlorobenzyl)-4-hydroxy-
CAS REGISTRY NUMBER :
81-82-3
BEILSTEIN REFERENCE NO. :
1689759
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C19-H15-Cl-O4
MOLECULAR WEIGHT :
342.79
WISWESSER LINE NOTATION :
T66 BOVJ DY1V1&R DG& EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
187 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,186,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
33 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,186,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
392 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 30,531,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
221 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 30,531,1995

 Safety Information

Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H373-H412
Precautionary Statements P273
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R48/22;R52/53
Safety Phrases S37-S61
RIDADR UN 2811 6.1/PG 1
WGK Germany 2
RTECS GN4830000
Packaging Group II
Hazard Class 6.1(a)

 Articles9

More Articles
A chiral separation strategy for acidic drugs in capillary electrochromatography using both chlorinated and nonchlorinated polysaccharide-based selectors.

Electrophoresis 35(19) , 2807-18, (2014)

A generic chiral separation strategy for the analysis of acidic compounds in CEC is proposed in completion of an earlier defined strategy for nonacidic compounds. The screening step of this strategy u...

Single-step approach for fabrication of vancomycin-bonded silica monolith as chiral stationary phase.

J. Chromatogr. A. 1358 , 208-16, (2014)

A vancomycin-bonded silica monolithic column for capillary electrochromatography (CEC) was prepared by a single-step in situ sol-gel approach. This sol-gel process incorporates a synthetic sol-gel pre...

Toxicology and histopathology of some rodenticides and palatable food items combinations on the common mice Mus musculus var. albus in Egypt.

Commun. Agric. Appl. Biol. Sci. 68(4 Pt B) , 771-87, (2003)

In this study the palatability tests of certain food items as attractants in the poisoned-baits for the albino mouse Mus musculus var. albus showed that the food items of treacle, maize oil, dry or we...

 Synonyms

UNII:UCD8XZW42P
3-(1-(4-Chlorophenyl)-3-oxobutyl)-4-hydroxy-2H-1-benzopyran-2-one (9CI)
MFCD00012094
2H-1-Benzopyran-2-one, 3-[1-(4-chlorophenyl)-3-oxobutyl]-4-hydroxy-
3-(a-Acetonyl-p-chlorobenzyl)-4-hydroxycoumarin
tomorin
3-[(1RS)-1-(4-chlorophenyl)-3-oxobutyl]-4-hydroxycoumarin
3-(a-p-Chlorophenyl-b-acetylethyl)-4-hydroxycoumarin
3-[1-(4-Chlorophenyl)-3-oxobutyl]-4-hydroxy-2H-1-benzopyran-2-one
Coumachlor
Geigy Rodenticide Exp.332
FAMARIN
rac-3-[(1R)-1-(4-chlorophenyl)-3-oxobutyl]-4-hydroxy-2H-1-benzopyran-2-one
3-[1-(4-Chlorophenyl)-3-oxobutyl]-4-hydroxy-2H-chromen-2-one
ratilan
P-CHLOROWARFARIN
cumachloor
kumachlor
(±)-3-(1-(p-Chlorophenyl)-3-oxobutyl)-4-hydroxycoumarin
EINECS 201-378-1
(±)-Coumachlor
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