Concanamycin B

Modify Date: 2024-01-10 18:08:57

Concanamycin B Structure
Concanamycin B structure
Common Name Concanamycin B
CAS Number 81552-33-2 Molecular Weight 852.059
Density 1.2±0.1 g/cm3 Boiling Point 960.2±65.0 °C at 760 mmHg
Molecular Formula C45H73NO14 Melting Point N/A
MSDS N/A Flash Point 534.5±34.3 °C

 Use of Concanamycin B


Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases

 Names

Name concanamycin b
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 960.2±65.0 °C at 760 mmHg
Molecular Formula C45H73NO14
Molecular Weight 852.059
Flash Point 534.5±34.3 °C
Exact Mass 851.503113
PSA 225.92000
LogP 3.34
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.556

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GK6889000
CHEMICAL NAME :
Concanamycin A, 8-deethyl-8-methyl-
CAS REGISTRY NUMBER :
81552-33-2
LAST UPDATED :
199303
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C45-H73-N-O14
MOLECULAR WEIGHT :
852.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 37,1333,1984

 Synonyms

8-Deethyl-8-methylconcanamycin A
ConcanaMycin B (high purity)
L-glycero-Pentopyranose, 3-O-[4-O-(aminocarbonyl)-2,6-dideoxyhexopyranosyl]-2,4-dideoxy-1-C-[(3S)-3-[(4E,6E,11S,12R,13R,14E,16Z)-10,12-dihydroxy-3,17-dimethoxy-7,9,11,13,15-pentamethyl-18-oxooxacycloo ;ctadeca-4,6,14,16-tetraen-2-yl]-2-hydroxy-1-methylbutyl]-4-methyl-5-C-[(1E)-1-propen-1-yl]-, (4ξ)-
(4ξ)-3-O-(4-O-Carbamoyl-2,6-dideoxyhexopyranosyl)-2,4-dideoxy-1-C-{(4S)-4-[(4E,6E,11S,12R,13R,14E,16Z)-10,12-dihydroxy-3,17-dimethoxy-7,9,11,13,15-pentamethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen -2-yl]-3-hydroxy-2-pentanyl}-4-methyl-5-[(1E)-1-propen-1-yl]-L-glycero-pentopyranose
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