Cyclizine

Modify Date: 2024-01-09 12:25:55

Cyclizine Structure
Cyclizine structure
 Common Name Cyclizine
CAS Number 82-92-8 Molecular Weight 266.38100
Density N/A Boiling Point N/A
Molecular Formula C18H22N2 Melting Point N/A
MSDS N/A Flash Point N/A

 Names

Name cyclizine
Synonym More Synonyms

 Chemical & Physical Properties

Molecular Formula C18H22N2
Molecular Weight 266.38100
Exact Mass 266.17800
PSA 6.48000
LogP 2.89920

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL6475000
CHEMICAL NAME :
Piperazine, 1-(diphenylmethyl)-4-methyl-
CAS REGISTRY NUMBER :
82-92-8
BEILSTEIN REFERENCE NO. :
0230441
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C18-H22-N2
MOLECULAR WEIGHT :
266.42
WISWESSER LINE NOTATION :
T6N DNTJ AYR&R& D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
126 mg/kg/6W-I
TOXIC EFFECTS :
Blood - agranulocytosis
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 292,174,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
147 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,218,1972 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
450 mg/kg
SEX/DURATION :
female 10-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 109,323,1970
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
450 mg/kg
SEX/DURATION :
female 10-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Effects on Newborn - stillbirth
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 109,323,1970 *** REVIEWS *** TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966

 Safety Information

Hazard Codes T+
HS Code 2933599090

 Synthetic Route

methylpiperazine structure

methylpiperazine

CAS#:109-01-3

benzhydryl chloride structure

benzhydryl chloride

CAS#:90-99-3

~30%

Cyclizine Structure

Cyclizine

CAS#:82-92-8

Literature: US2009/176792 A1, ; Page/Page column 26 ;
N-Methyldiethanolamine structure

N-Methyldiethan...

CAS#:105-59-9

diphenylmethylamine structure

diphenylmethylamine

CAS#:91-00-9

~18%

Cyclizine Structure

Cyclizine

CAS#:82-92-8

Literature: Journal of Organic Chemistry, , vol. 50, # 9 p. 1365 - 1370
Piperazine structure

Piperazine

CAS#:110-85-0

Bromodiphenylmethane structure

Bromodiphenylmethane

CAS#:776-74-9

methyl iodide structure

methyl iodide

CAS#:74-88-4

~43%

Cyclizine Structure

Cyclizine

CAS#:82-92-8

Literature: Journal of the American Chemical Society, , vol. 119, # 14 p. 3288 - 3295
1-benzhydryl-4-(ethoxycarbonyl)piperazine structure

1-benzhydryl-4-...

CAS#:102552-76-1

~%

Cyclizine Structure

Cyclizine

CAS#:82-92-8

Literature: BE539693 , ;

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Ciclizina
Marzine
N-benzhydryl-N'-methylpiperazine
Valoid
Bw 47-83
Marazine
1-Benzhydryl-4-methyl-piperazin
Emoquil
Nautazine
Marezine
Wellcome
CYCLIZINE HCL
1-diphenylmethyl-4-methylpiperazine
1-benzhydryl-4-methyl-piperazine
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Chemsrc provides Cyclizine(CAS#:82-92-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Cyclizine are included as well.>> amp version: Cyclizine

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