Ozagrel

Modify Date: 2024-01-02 05:41:29

Ozagrel Structure
Ozagrel structure
 Common Name Ozagrel
CAS Number 82571-53-7 Molecular Weight 228.247
Density 1.2±0.1 g/cm3 Boiling Point 468.0±25.0 °C at 760 mmHg
Molecular Formula C13H12N2O2 Melting Point 223 - 224ºC
MSDS N/A Flash Point 236.8±23.2 °C

 Use of Ozagrel


Ozagrel(OKY-046) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.Target: Thromboxane A2 SynthaseOzagrel was selected as the best compound of highly selective inhibitors of TXA2 synthase. The inhibition of TXA2 synthase by ozagrel was more effective on human and rabbit enzymes than those of other species. Ozagrel increased 6-keto-PGF1 alpha, one of stable metabolites of PGI2, in various isolated cells and tissues perhaps via accumulated PG endoperoxides resulted by the inhibition of TXA2 synthase [1]. Ozagrel was estimated to be a reversible mixed-type inhibitor of diphenolase activity with the constants (K (S1), K (S2), K (i1), and K (i2)) determined to be 2.21, 3.89, 0.454, and 0.799 mM, repectively [2]. Infusion of OKY-046 significantly inhibited pulmonary thromboxane B2 delivery, attenuated the early increase in pulmonary vascular resistance, and blocked the increase in systemic vascular resistance. In addition, OKY-046 blunted and delayed the decrease in cardiac output and maintained end-systolic pressure-diameter relation, +dp/dt, and lung lymph flow at baseline values [3].

 Names

Name (E)-3-[4-(imidazol-1-ylmethyl)phenyl]prop-2-enoic acid
Synonym More Synonyms

 Ozagrel Biological Activity

Description Ozagrel(OKY-046) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.Target: Thromboxane A2 SynthaseOzagrel was selected as the best compound of highly selective inhibitors of TXA2 synthase. The inhibition of TXA2 synthase by ozagrel was more effective on human and rabbit enzymes than those of other species. Ozagrel increased 6-keto-PGF1 alpha, one of stable metabolites of PGI2, in various isolated cells and tissues perhaps via accumulated PG endoperoxides resulted by the inhibition of TXA2 synthase [1]. Ozagrel was estimated to be a reversible mixed-type inhibitor of diphenolase activity with the constants (K (S1), K (S2), K (i1), and K (i2)) determined to be 2.21, 3.89, 0.454, and 0.799 mM, repectively [2]. Infusion of OKY-046 significantly inhibited pulmonary thromboxane B2 delivery, attenuated the early increase in pulmonary vascular resistance, and blocked the increase in systemic vascular resistance. In addition, OKY-046 blunted and delayed the decrease in cardiac output and maintained end-systolic pressure-diameter relation, +dp/dt, and lung lymph flow at baseline values [3].
Related Catalog
References

[1]. Nakazawa, M., et al., [Research and development of ozagrel, a highly selective inhibitor of TXA2 synthase]. Yakugaku Zasshi, 1994. 114(12): p. 911-33.

[2]. Li, S.B., et al., In vitro effect of ozagrel on mushroom tyrosinase. Protein J, 2009. 28(3-4): p. 182-8.

[3]. Westphal, M., et al., Selective thromboxane A2 synthase inhibition by OKY-046 prevents cardiopulmonary dysfunction after ovine smoke inhalation injury. Anesthesiology, 2005. 102(5): p. 954-61.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 468.0±25.0 °C at 760 mmHg
Melting Point 223 - 224ºC
Molecular Formula C13H12N2O2
Molecular Weight 228.247
Flash Point 236.8±23.2 °C
Exact Mass 228.089874
PSA 55.12000
LogP 1.65
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.593

 Safety Information

Hazard Codes Xn,Xi
Risk Phrases R22:Harmful if swallowed.
Safety Phrases S36
RIDADR 3249
WGK Germany 3
RTECS US4025000
Packaging Group III
Hazard Class 6.1(b)

 Synonyms

p-(1-imidazolylmethyl)cinnamic acid
Ozagrelum
2-Propenoic acid, 3-[4-(1H-imidazol-1-ylmethyl)phenyl]-, (2E)-
Xanbon
(E)-4-(1-imidazolylmethyl)cinnamic acid
Ozagrel
(E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]-2-propenic acid
(2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]prop-2-enoic acid
Cataclot (TN)
2-Propenoic acid,3-(4-(1H-imidazol-1-ylmethyl)phenyl)-,(E)
OKY 046
Ozagrelum [Latin]
MFCD00868231
(E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic Acid
(E)-4-(Imidazol-1-ylmethyl)cinnamic Acid
(2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]acrylic acid
Cataclot
(E)-3-(4-((1H-imidazol-1-yl)methyl)phenyl)acrylic acid
Ozagrel (INN)
EINECS 242-903-4
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