(3R)-2,3-Dihydro-5,7-dihydroxy-3-[(4-hydroxyphenyl)methyl]-4H-1-benzopyran-4-one

Modify Date: 2024-02-27 16:34:13

(3R)-2,3-Dihydro-5,7-dihydroxy-3-[(4-hydroxyphenyl)methyl]-4H-1-benzopyran-4-one Structure
(3R)-2,3-Dihydro-5,7-dihydroxy-3-[(4-hydroxyphenyl)methyl]-4H-1-benzopyran-4-one structure
Common Name (3R)-2,3-Dihydro-5,7-dihydroxy-3-[(4-hydroxyphenyl)methyl]-4H-1-benzopyran-4-one
CAS Number 849727-88-4 Molecular Weight 286.279
Density 1.5±0.1 g/cm3 Boiling Point 574.8±39.0 °C at 760 mmHg
Molecular Formula C16H14O5 Melting Point N/A
MSDS N/A Flash Point 220.0±20.6 °C

 Use of (3R)-2,3-Dihydro-5,7-dihydroxy-3-[(4-hydroxyphenyl)methyl]-4H-1-benzopyran-4-one


(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, a homoisoflavonoid, has antiangiogenic activity against human retinal microvascular endothelial cells[1].

 Names

Name (3R)-5,7-Dihydroxy-3-(4-hydroxybenzyl)-2,3-dihydro-4H-chromen-4-one
Synonym More Synonyms

  Biological Activity

Description (R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, a homoisoflavonoid, has antiangiogenic activity against human retinal microvascular endothelial cells[1].
Related Catalog
In Vitro (R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone has an GI50 value of 35.8 µM on proliferation of human retinal microvascular endothelial cells (HRECs)[1]. (R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone (10 µM, 30 µM, and 100 µM; 8 hours) significantly decreases HRECs overall tubule formation and in a dose-dependent manner[1].
References

[1]. Sianne L Schwikkard, et al. Antiangiogenic Activity and Cytotoxicity of Triterpenoids and Homoisoflavonoids from Massonia pustulata and Massonia bifolia. Planta Med. 2018 Jul;84(9-10):638-644.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 574.8±39.0 °C at 760 mmHg
Molecular Formula C16H14O5
Molecular Weight 286.279
Flash Point 220.0±20.6 °C
Exact Mass 286.084137
LogP 3.65
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.684

 Synonyms

(3R)-5,7-Dihydroxy-3-(4-hydroxybenzyl)-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-3-[(4-hydroxyphenyl)methyl]-, (3R)-